Old friends Sean (the family man) and Christian (the playboy) are partners in a plastic surgery office. Their relationship is under fire after Christian operates on a Colombian drug lord who pays him in drug money. Sean's family life is also in upheaval, and he is headed for a mid-life crisis.

Twin sisters want plastic surgery done to look different from each other. Sean moves out so he can experience life as a single man. Matt decides to try and perform a circumcision on himself after his girlfriend sees his penis. Christian is plagued with thoughts of Julia.

Sean and Julia discover Matt has tried to circumcise himself. The business is sued by a faithful client after Sean accidentally leaves a surgical tool inside of her body. Meanwhile, Christian and Grace struggle with a mentally unstable patient.

Two recurring characters are introduced in an episode that teaches the odd-couple plastic surgeons a few lessons about moral boundaries. Patti D'Arbanville plays Wallis Forsythe, a pornography mogul who meets Christian at a party and agrees to send some business his way. And Joey Slotnick plays Merrill Bobolit, a hack surgeon who's more successful than Sean and Christian because of his willingness to take on any client. Forsythe's easy money and Bobolit's sleazy competition inject a dose of conflict into Sean and Christian's partnership--as if it needed any more of it!

Someone is vandalizing Christian's possessions, and he attempts to find the culprit. A chemotherapy patient who is considering breast implants brings excitement to Sean's life, and Matt finds himself in a threesome with Vanessa and Riley.

Christian's difficulties with Kristin are exacerbated when his feelings for Julia are revealed. Jude is hired as an intern, to sexy and disastrous results. Matt is caught mid-threesome by Julia.

Matt accidentally hits Cara with Henry's car, and calls Sean in to help when Cara's mother, for religious reasons, refuses drugs and surgery to treat her injuries. Christian discovers that a patient used plastic surgery to hide a revolting crime and it brings up terrible memories of his own childhood.

Sean and Jude's respective secrets are revealed, and Merril offers Christian an interesting trade: Kimber for a Lamborghini. Christian accepts, but Kimber discovers the truth and exacts a small revenge.

Sean and Christian learn that they have to take a test in order to continue practicing. Sean and Megan visit a doctor to learn that there is nothing they can do for her. Mrs. Grubman returns to get an operation on her and her fiancé. Christian passes his test, but Sean walks out. Megan commits suicide. Julia finds out about Sean's affair with Megan.

Ms. Caine wants an operation to get rid of her "cankles". Sean and Julia are still on the outs. Christian learns he's going to be a father. Julia steals Christian's brush to determine if he's the father of Matt. Sean and Grace learn that Ms. Caine has multiple personalities. Cara recovers and gets close with Matt and Henry. Henry develops feelings for her. Cara asks Matt to the prom. Henry tells Matt that he is going to confess to Cara what happened.

Sean and Christian are reunited with an old friend, Julia bonds with Sofia Lopez, and Christian and Gina clash over their differences in opinion concerning Gina's pregnancy.

Christian learns that Kimber and Merril are engaged. Escobar continues to have the surgeons do things for him. Liz is sent to Bermuda after being shot in the leg by one of Escobar's people. Sean goes to kill Escobar. Escobar makes a deal with Sean; a new face for their freedom. Christian learns, in the delivery room, that he is not the father of Gina's baby. Julia returns to get the paternity test she had done a while ago. The doctors do surgery on Escobar, and give him the face of a criminal even higher than Gallardo on the Most Wanted List - Armand Ortiz. Ortiz is arrested at the airport for bank robbing and killing a federal agent.