Szörnyű démon telepszik az álmos texasi kisvárosra. A rejtélyes, láthatatlan erő hatására az emberek teljesen megbolondulnak, és megkísérlik halomra gyilkolni egymást. Reddle seriff azt gondolja, hogy valami kapcsolat van eközött a rejtélyes erő és az anyja halála között. Szerinte ez az átkozott valami késztette arra az apját, hogy huszonöt esztendővel ezelőtt megölje az anyját. A seriff megpróbálja megállítani a rettenetet, mielőtt az megtizedelné a városka lakóit.

A young couple moves into a new home only to find out that their neighbor, a seemingly normal man who works from home is not what he seems.

A lone vampire punishes two teenage boys who make the poor decision to break into a mortuary.

Based on a short story by Mike O’Driscoll. The story of Larry Pearce, an ordinary man blessed with gift/curse of extraordinary hearing that drives him to the brink of insanity, and forces him to take violent action to silence the horrific cacophony in his head.

Pro-Life tells the story of a young girl trapped inside a clinic who discovers the only thing more dangerous than her pursuers is the demonic secret that she carries within her.

Pelts is an erotic tale about stolen raccoon pelts that take violent revenge on those who seek to wear them.

Deadly virus infects the nation, that turns men into psychotic killers who attack every woman they see. A housewife and her daughter try to survive this madness.

Rob Hanisee is a writer that has a strange apparition. Beautiful, naked and mysterious, Valerie might be the muse that Rob has always searched for - or the manifestation of a much darker force. Blood and death follow Rob across the line between life and art.

Her flesh has been burned and her body remains in coma but from a medical perspective, Abby is still alive. Her husband Cliff is determined to get a court order to stop her pain. But Abby's condition is worsening, she repeatedly flat-lines and is revived. Each time her body dies, her spirit grows stronger attacking those that have taken advantage of her plight.

A long time ago, a prank by a gang of kids known as the West End Bunch went wrong. Now grown up and a parent himself, former West-Ender Layne Banixter witnesses the friends of his youth murdered by their own children, who have turned against them. To save his own family Layne must face his fears and realize that sometimes the sins of the fathers are visited upon the son.

Edgar Allan Poe is a writer out of ideas and short on cash that's followed by a black cat that will destroy his life or help him to write one of his most famous stories.

"The Washingtonians" is the twelfth episode of the second season of Masters of Horror, directed by Peter Medak. The episode is based on the short story written by Bentley Little. It details a man discovering a shocking secret about George Washington that could shatter the world's view of America forever, and the murderous brotherhood sworn to keep the secret safe.

Dream Cruise is the thirteenth and final episode of the second season of Masters of Horror, directed by Norio Tsuruta.