11 year old Chyna starts her first day at High School as part of the Advanced Natural Talents (ANT) Program. There she meets Olive (who is smart) and Fletcher (who is a good artist and has a crush on Chyna). Chyna's two new friends help her learn the ropes of her new school. But, Chyna of course doesn't fit in. So, she decides to sneak into a party and show the High Schoolers what shes got. But, Olive, Fletcher and Cameron (Chyna's brother) might ruin her chances.

Chyna decides to get involed in some clubs and sports and joins Cheerleading. Inspired by their friend Olive and Fletcher start a lunch club.

Chyna, Fletcher and Olive all participate in the science fair.

After being denied an entrance to a school dance, Olive tricks Chyna into running for student council, Angus then tells her that to run for A.N.T. rep you need to participate in every school activity and Olive was the runner up. So Chyna tricks Olive into running too. Meanwhile, Fletcher feels ignored from China so then Angus then tells him in order to get a girl to like you you first need to relate with their dad. Fletcher then befriends Chyna's dad to see if he has a possibility with China but Cameron gets jealous. At the end, Cameron beats Chyna and Olive for student council and Chyna's dad starts hanging out with Cameron again

Fletcher tries to impress Chyna, but she is too concerned about Gibson after he tells her that he has been feeling lonely. Chyna and Fletcher find out that Sofie, Gibson's ex-girlfriend from his childhood, is in jail for a robbery. So they take Gibson to the jail to show him that Sofie is a criminal, so he can get over her and hopefully stop spending all his time with Chyna and Fletcher. Meanwhile, Lexi tries to get on the front page of the news, but must show Olive that she's done something newsworthy.

After Darryl gets Chyna a bag from the evidence locker at the police station and finds a new designer bag inside it, he accuses her of shoplifting and sends a police officer undercover. When Chyna, Fletcher, and Olive find out that "Charlie Brown" is a cop and that he is spying on them, they pretend that they are robbing a house.

Chyna falls for a new student in the A.N.T. Program from England. He's another artistic genius who goes to school as a robot. But when Chyna tries to ask him out, he asks for advice from Fletcher. Chyna tells Fletcher there's a artistic guy that she is secretly in love with, and if she should ask him out. and Fletcher thinks she is thinking about him. But when he finds out that Chyna and the new kid from England are going out, Fletcher gets help from Angus to sabotage the date. Meanwhile, Darryl challenges Olive and Cameron at the arcade to see who can get the highest score on a game, Donkey King.

Principal Skidmore gives out awards to every student for having talent except Cameron, so Chyna tries to help him find his talent.

Chyna gets the chance to have a recording contract, and she has to make a decision between being famous or losing her friends.

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Chyna and Fletcher meet Zanko (Ernie Grunwald), Fletcher's favorite artist. Zanko is having trouble with inspiration, so Chyna urges Fletcher to give Zanko one of his paintings to inspire him. But when Zanko passes the painting off as his own at his comeback party, Chyna creates an elite team to rescue the painting and gets the help of Olive, Angus, and "Wacky, the Wolf". Meanwhile, Paisley and Lexi audition to be a princess for a kid's birthday party for Chyna's mom, Roxanne.

Olive becomes a history teacher.

It’s Halloween at Webster High School and it’s Chyna Parks’ first day in the Mutant Program, where monsters go to school with normal high school students. Chyna is Medusa so she fits right in with her new Mutant Program friends: Olive, a mad scientist, Fletcher, a vampire and Angus, a zombie. However, Lexi and the normal kids are terrified of the mutants, so Gibson pairs everybody off to help prepare for the Halloween dance.

Chyna is overheard singing by pop superstar Madam Goo Goo, and is totally star-struck when she is given Goo Goo’s phone number so they can work together on a song. However, when the ANTs go on a field trip to a fortune cookie factory, Chyna realizes she lost Goo Goo’s number. So Olive, Fletcher and Angus help retrace Chyna’s steps back to the factory to find the misplaced number. Meanwhile, Lexi finds out she wasn’t invited to a fellow cheerleaders birthday party.

Olive loses her memory after hearing a loud noise and is kicked out of the A.N.T. Program by Principal Skidmore.

Lexi decides to have a sleepover party and not invite the ANTs, so Chyna invites Olive to sleep over at her house.

Chyna and Lexi both get picked as finalists for the reality show "America Needs Talent" and they end up having to pretend to be best friends.

Chyna, Olive and Fletcher make toys for kids at an orphanage, but then learn that Principal Skidmore is actually selling the toys for profit. Meanwhile, Lexi and Paisley are hired by a mall gift-wrapping

Chyna lands the lead in the school musical, but jealous Lexi tries to sabotage the show. Meanwhile, Cameron learns that a teacher is living at school and offers to rent his family's living room to the man.

Chyna, Olive, Fletcher, and Angus want to go to an upcoming concert with older kids, but they know Chyna's mom will never let them go. In order to convince her, they pretend they're going to see a kid's band, which backfires when she decides to tag along. Meanwhile, Cameron tries to get backstage at the concert.

Chyna and Fletcher go on a double date together. Meanwhile, Gibson takes over as cheerleading coach

Olive and Fletcher exclude Chyna from their product idea. Meanwhile, Paisley gets attention from her injuries and Lexi get jealous.

Violet, a sports prodigy with slight anger issues, joins the A.N.T. Program. Violet is not afraid of the older kids, including Lexi, who orders Chyna to keep the girl far away from her. Meanwhile, some of the older students take a drivers-education class.

Olive is shocked to discover that her pet robot, Hegel, is no longer functioning and has suspicious screwdriver scratches on his back. When a screwdriver is found in Chyna's locker, Chyna suspects that she has been framed and vows to find the real culprit. In the end, it is revealed that Chyna accidentally overfed Hegel.