Спустя год после того, как он стал Человеком-Пауком, Ник Фьюри пригласил Питера Паркера тренироваться с Ш.И.Т. Спайди отказывает Фьюри, но вскоре обнаруживает, что злодейские силы могут потребовать от него вступления в высшую лигу.

Человек-паук принимает предложение Ника Фьюри стать Великим Человеком-Пауком и встречает своих новых союзников молодых героев. Тем временем Норман Осборн приказывает доктору Осьминогу послать Ужасную четверку против Человека-паука.

После того, как спор между Человеком-пауком и Новой охватил всю команду, супер-юнцы просматривают базу данных наиболее разыскиваемых суперзлодеев Ш.И.Т.а, чтобы узнать, кого они могут победить и задержать, чтобы произвести впечатление на Ника Фьюри. «Человек-паук» и его команда отправляются в Латверию, чтобы выследить Доктора Дума.

Под наблюдением Осборна доктор Октавиус получает образец крови Человека-паука, чтобы создать смое могущественное существо. Тем временем Питер пытается сбалансировать свою дружбу с Гарри, со своим временем и с товарищами по команде ЩИТА.

Когда Человек-Паук встречает своего кумира Железного Человека, он получает специальный подарок: костюм Железного Паука. Однако, Человек-паук испытывает трудности с обучением использованию костюма и начинает пренебрегать своими товарищами по команде.

Таскмастер проникает в школу, чтобы разыскать Человека-паука. Человек-паук и Белая Тигрица должны отложить в сторону свои разногласия и найти способ победить противника.

Человек-паук соглашается на видео-интервью с подающей надежды журналисткой Мэри Джейн Уотсон. Человек-паук и Невероятный Халк вступят в битву против Ззакса на Манхэттене.

It is bad enough Spider-Man catches a cold, but things drop from bad to worse when a new Spider-Man dressed in black attempts to replace him. Are his friends right and is his jealousy is getting the best of him, or is the new Spider-Man Venom's latest victim?

While on a field trip, Spider-Man and his superhero friends encounter the mighty Thor, who is transformed into a frog by his mischievous half-brother Loki. Now, the heroes must venture to the magical world of Asgard in order to save the nine realms from Loki's wrath.

Spider-Man and Wolverine must overcome clashing personalities and styles in order to defeat Mesmero and Sabretooth.

Venom resurfaces, using Harry as his host, yet again, and this time Harry's neglecting father becomes his main target. While Norman Osborn does not want his potential secret weapon damaged, Spider-Man is confronted with the dilemma of either trying to help Harry on his own or putting his trust in his teammates, who have orders from Fury to finish Venom off.

After a fight with Whirlwind, Spider-Man insists on a weekend off from Nick Fury and S.H.I.E.L.D.. Unfortunately, Doctor Octopus chooses this very time to attack Spider-Man when his job is threatened by Norman Osborn.

When New York is plunged into a mystical sleep, Iron Fist and Spider-Man (who is at first highly sceptical of magic) seek the help of Doctor Strange. In order to break the spell, the three heroes must face their own worst fears in the face of the spell's initiator, the extradimensional entity known as Nightmare.

Peter Parker scrambles to focus his attention between completing his science fair project with Luke Cage and combatting Juggernaut. In his desperation concerning the first case, he decides to "borrow" one of Dr. Connor's inventions ... which (literally) becomes an even bigger threat to the city.

After being late for training, Spider-Man is faced against an evil super army called Zodiac and their leader, Scorpio, who took over the S.H.I.E.L.D. Helicarrier and set it on self-destruct. Spider-Man and Fury must put their differences aside and fight the new menace as a team.

Spider-Man and his team are put on S.H.I.E.L.D. security detail to protect the all-too-critical-for-his-own-health J. Jonah Jameson from the Beetle, a prospect Spider-Man does not enjoy. Things do get personal when Spider-Man must also protect a highly determined Mary Jane, who is on her way to the Bugle for a job interview, from the high-tech villain.

When Phil Coulson wants the heroes to report to the S.H.I.E.L.D. ice base for winter survival training, Spider-Man and his team sneak off for a vacation on a deserted tropical island that Nova finds under "classy." However, they soon realize something is not right with the island and the Sandman will make sure they never leave.

When Spider-Man and his fellow teenage super heroes cause too much damage in a super villain fight, Nick Fury assigns them to work with the super clean-up company Damage Control. While working with Damage Control, Spider-Man uncovers a villainous mystery.

Hulk smashes back into Spider-Man’s life where he is sick with an alien infection caused by the Phalanx. Spider-Man has no choice but to take Hulk home and keep him hidden from Aunt May while protecting him from the Phalanx.

Loki exacts revenge on Spider-Man by turning him into a pig, just in time for the Asgardian Boar Hunt across New York City. Now, Thor, who knows all too well how it feels to be transformed into a helpless animal, must help Spider-Ham survive.

Flash Thompson stars as Spider-Man in a Midtown High musical production, and gets a taste of what Spider-Man's life is really like when the Trapster mistakes the football jock for the real web-slinger.

Spider-Man loses Captain America's shield and must retrieve it from Doctor Doom.

Aunt May goes on a date with Phil Coulson, Peter's principal and S.H.I.E.L.D. supervisor, and the Beetle returns to continue his evil deeds.

The Green Goblin is created.

Spider-Man tries to protect Harry Osborn from the Green Goblin and Venom.