Detective Jane Rizzoli and medical examiner Maura Isles investigate the grisly murder of a wealthy couple. The M.O. matches the work of a serial killer known as the Surgeon, who once nearly murdered Jane. Now that the Surgeon is behind bars, it seems one of his proteges is picking up where he left off.

Jane and Maura investigate the mysterious death of a young boy whose family is from Cape Verde. It appears at first that he may have died during an attempted exorcism, and it may take a message from beyond the grave for Jane to pinpoint exactly what happened. Jane is distracted from the case when her mother sets her up on a surprise date.

After a student is gunned down in broad daylight, the investigation reveals she had more than a few secrets. Meanwhile, Jane’s mother Angela gets into a spat with her father over the car.

The eldest brother in a Boston “Brahmin” family (direct descendents of passengers on the Mayflower) is found in the harbor dead after an apparent sailing accident. But Maura’s close connection with the family and Jane’s resentment over the wealth they display threaten to derail their investigation. Angela, meanwhile, tries her hand at selling a Polynesian health drink.

Jane and Maura investigate what appears to be a hate crime, the brutal assault and murder of a woman leaving a lesbian bar. With Jane going undercover, they hope to lure the killer out in the open. Off the job, Maura hooks Jane up with a handsome yoga instructor.

The Boston Marathon turns into a crime scene when a shooter begins targeting runners. Racing to catch the killer before another shooting, Jane and Maura must conduct their investigation in secret so as not to cause a mass panic.

Puistosta löydetään pakastimessa jäädytetty mies, joka paljastuu pari vuotta aiemmin kadonneen avioparin toiseksi osapuoleksi. Miestä on käsitelty skalpellilla, ja Janen elämä ja työ menevät sekaisin, kun käy ilmi, että hänen vainoojansa Hoyt on jälleen kuvioissa toimien tällä kertaa vankilasta käsin uuden apurin välityksellä. Frankie puolestaan löytää tyttöystävän, jonka kanssa hän etenee hämmästyttävää vauhtia: tyttö intoutuu jopa valmistamaan ruokaa Janelle. Entä missä piilee kuolleen miehen aviovaimo? Vastauksia haetaan häijyltä Hoytilta itseltään, ja Gabriel haluaa rentouttaa Janea treffien merkeissä. Amerikkalainen rikossarja, jossa kaksi vahvaa uranaista panee Bostonin kuriin ja järjestykseen.

An investigation leads Jane into Boston's checkered past when an identity thief is murdered; Maura goes on a personal quest.

After an undercover cop working a narcotics-smuggling sting is shot dead, the killers next turn their sites on Boston homicide headquarters, leaving Jane, Maura and Frankie Jr. trapped in a fight for survival on their home turf. It's a situation that will force Maura to challenge herself like never before. On the home front, Jane's parents are excited that their oldest child, Tommy, is being released after serving time in prison.