A female jogger is found dead in Schuylkill River and Megan teams up with medical investigator Peter Dunlop to investigate her whereabouts before her murder. Meanwhile, Megan spends the day trying to solve a personal problem concerning her daughter's birthday.

When a young, interracial couple is found shot and killed inside their car in Fairmont Park, Dr. Megan Hunt promises the grieving parents that their daughter’s killer will be found. Detectives Bud Morris and Samantha Baker are ready to chalk the case up to a murder-suicide, but Megan and her team find evidence on the bodies that sends the case in an entirely different and shocking direction. Meanwhile, Peter advises Megan not to push too hard when it comes to reconnecting with her daughter, Lacey.

Megan is surprised to discover she has a connection to a woman found dead in a hotel room; Megan starts taking an interest in what is going on around her.

Curtis questions Ethan's interest in the investigation of the mysterious death of a beautiful twin; Megan runs into resistance while investigating the death of a patient at the hospital where she used to work.

A magazine editor is found dead in her mansion; Megan confronts a suspect while at a social event with her mother; Ethan surprises Kate with his positive attitude.

A father is found stabbed to death in his home in the Philadelphia suburbs; Kate takes a consulting role in a case with Megan's ex-husband.

Megan and the team investigate when a Philadelphia homicide detective is killed in a hit-and-run; Megan turns to her mother (Joanna Cassidy) for help.

Megan suspects foul play when a young philanthropic socialite dies; the investigation is interrupted by Kate's personal life.