Jaime goes undercover with a deadly human trafficking ring. Danny and Baez investigate a homicide connected to Darryl Reid, Danny's old partner. Also, Frank grapples with whether to publicly support Mayor Chase on a policy decision and Eddie is determined to teach a young shoplifter a lesson.

Danny and Baez join forces with Danny's old partner, Jackie Curatola, when a serial killer reappears. Also, Eddie faces backlash when she tries to help a woman who accuses a sergeant of rape.

Frank grapples with the personal loss of his best friend and how best to help Tess Ross, the daughter of his best friend, when she lands in jail. Also, Jaime and his nephew, Joe Hill, race against the clock to reunite a trafficking victim with her sister; and Danny and Erin clash when she goes behind Danny's back to use his criminal informant in an investigation.

Erin is designated to lead a federal investigation into corrupt horse racing. Also, Jamie investigates a drug trafficking operation involving rival gangs and Danny and Baez look into a series of assaults in Little Vietnam with the help of a familiar face.

Danny and Baez investigate a homicide involving voodoo with the help of Baez's old partner. Also, Eddie and a fellow officer team up with Captain McNichols when they suspect a prestigious school is employing discriminatory admission practices.

Jamie works to bust a group of scammers who use artificial intelligence to defraud the elderly. Also, Danny and Baez investigate a series of mysterious deaths at a hospital; Anthony is determined to take down an attorney who exploits the law for his own financial gain; and Frank disapproves when he learns Gormley is planning to face off against fellow officers in a "smoker" boxing match.

Danny and Baez are on edge when Sam Evans, a serial killer who once targeted Baez and her daughter, is released early from prison. Also, Jamie and Anthony team up on an investigation involving one of Anthony's criminal informants, his ex-wife’s brother; Eddie clashes with Captain McNichols over a sergeant who keeps downgrading her cases; and Frank is upset when Abigail goes behind his back regarding a professional favor for her husband.

Danny gets involved when Sean becomes the latest victim in a series of robberies on Sean's college campus. Also, Erin grows suspicious of an overworked attorney who she believes isn't acting in his client's best interest.

Danny and Gormley race to find Gus Vanderlip, a committed detective who is dangerously determined to uncover how a rapist he arrested is back on the streets; on the eve of their anniversary, Jamie and Eddie are sent on an undercover assignment to expose a corrupt sober living house; and Henry asks Frank for a favor regarding the NYPD's 9/11 Victims Compensation Fund.