In front of a live audience of 14,000 at London's O2 arena Alan Carr, Andy Parsons, Bill Bailey, Catherine Tate, Christine Bleakley, David Mitchell, The Fonejacker, Jack Whitehall, Jack Dee, James Corden, Jason Manford, Jo Brand, John Bishop, Jonathan Ross, Kevin Bridges, Kevin Eldon, Lee Evans, Mark Watson, Michael McIntyre, Noel Fielding, Patrick Kielty, Rich Hall, Rob Brydon, Ruth Jones, Sean Lock, and Shappi Khorsandi take turns on stage to make it the biggest live stand up show in UK history. Added to this, Stomp perform two major routines with Alan Carr and Bill Bailey. Plus, Robert Webb, Ricky Gervais, Derren Brown, Kevin Bishop, Jimmy Carr, Gok Wan, Stephen Merchant and Johnny Depp provide additional sketches.

For one night only, the O2 Arena played host to Channel 4's Comedy Gala 2010, the UK's biggest stand-up show featuring 35 of the biggest and best comedians our homeland has to offer. They all performed in aid of Great Ormond Street Hospital. These are the Best Bits from the performance.