In der zweiten Staffel muss Josh damit zurechtkommen, dass er Nora zum Werwolf gemacht hat, während Aidan sich Vampiroberhaupt Mother anschließt.

Aidan tries to steer a leaderless Boston while resisting his deadlier vampire instincts as he finds himself tempted and tormented by a figure from his past. Sally must face the consequences of missing her door while figuring out how to navigate life on earth as a ghost. Josh searches for a cure for his condition while struggling to maintain his relationship with Nora and, like the rest of his roommates, trying to build a future for himself beyond simply being a monster.