The Tony Danza Show was a daytime variety talk show that premiered on September 13, 2004 in syndication and was distributed by Buena Vista Television. For its entire two-season run the show aired live in the Eastern Time Zone at 10 AM for markets that chose to carry it at that time. The Tony Danza Show was recorded at the ABC studio complex on Manhattan's Upper West Side.

The program was hosted by actor and New York native Tony Danza. For the first season Danza was joined by Ereka Vetrini as his co-host, with music provided by pianist Nadia DiGiallonardo. After the first season Vetrini, who gained fame appearing on The Apprentice, was let go from the program and DiGiallonardo took over most of her co-hosting duties.

On May 9, 2005, during a go-kart race with NASCAR star Rusty Wallace, Danza's kart flipped after Wallace accidentally bumped him. Danza suffered a concussion; neither he nor Wallace were wearing a helmet.

The most-viewed episode of the series featured the heavy metal band, The Tony Danza Tapdance Extravaganza, and their appearance followed an email from a viewer. The ratings, however, were not strong and in early March 2006, Danza told viewers that he was not sure if the program would return after a scheduled two-week hiatus. On March 24, 2006, the program returned with new episodes but after two more months The Tony Danza Show came to an end. The last live broadcast aired on May 26, 2006 with reruns continuing until September 15, 2006. VH1's The Best Week Ever then started an online petition to save the show.