Over the past two decades, Carol has hoarded her husband's home. Now, she's left her husband Dave to deal with the hoard and his failing health. With the mansion threatened to be condemned, the family unites to try to save the house and confront Carol about her behavior.

For two years Sherry has not paid the mortgage payments on her house. Her justification for her massive hoard is that it protects her from the outside world, resulting in a 6-foot-high wall of trash blocking entry into the home. Relationships are tested when Sherry attempts to work with her son and daughter to clear her massive hoard. With the help of the Hoarders team, Sherry must now cleanup her hoard to start getting her life on track.

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As a retired Architect Dennis sees the value in repurposing and using materials for all types of projects. This has led Dennis to collect a massive amount of clutter over the years. Being the primary care giver for his wife, he has no more time to spend completing projects he once desired to accomplish. Code Enforcement is concerned about the safety of Dennis' property. Now with the help of the Hoarders team of experts, either Dennis will clean up the property or Code Enforcement will take action and he will lose everything.

Flora's daughter and grandchildren recently moved in with her, but due to the massive hoard, the entire family must eat, sleep and live in a single bedroom; Dr. David Tolin and professional organizer Dorothy Breininger.

Code enforcement has been dealing with Cindy in court for years now; Cindy must deal with her hoarding tendencies to save her son's property and her storefront or lose everything.

John’s extreme hoard, rat infestation and mounting citations from the city is too much to handle. John must now cleanup or face losing not only his home, but his relationship with the woman he loves.