After blowing away a nuclear facility under the control of an aggressive world leader, MacGyver returns home for some peace and quiet, only to find his boss waiting for him. He advises MacGyver that a contract is out on his life and he needs to skip town for awhile.

While retrieving tickets for a hockey game at the Phoenix Foundation, MacGyver and his grandpa Harry get caught in the middle of a woman's plot to blow up the building using a bomb that she herself made. They try to escape, but are locked in. Now they must figure another way out before she activates the bomb.

MacGyver's friends throw a birthday party for him, but he's somberly reflecting on his past and future. While reflecting, MacGyver decides to leave the Phoenix Foundation to get married and have a family. Can Pete convince him of how important he is to the Foundation and get him to change his mind?

Frantic with worry about his gravely-ill Grandpa Harry, MacGyver experiences a strange near-death phenomena, seeing his parents again, when he's injured by a man who's stolen an ancient Egyptian relic.

When Mac tries to claim the station wagon left to him by his late Grandpa Harry, it starts a strange chase that leads him to an ex-con with a dream of running a restaurant, a soup kitchen in need of money, and a gang of crooks out for themselves.