Unit 13 is put on a grant fraud matter, after it is threatened to be disbanded. They track it down to a pharmaceutical company called MediGEN. Karin Prinsen finds secret plans which have serious impact for the Dutch infrastructure at her stepfather's, which she can handover right before she's killed.

Inspector Harry seems to have had an accident. Sterk confiscates a videotape of Rieding on which top civil servants make agreements with a criminal organization. Roberto goes undercover at MediGEN and journalist Remco Haas house has been burgled, the information of Karin Prinsen he got is missing.

The Unit gets a few days to close the investigation of the office Leenmans & Venhuis. Bilderdijk informs rieding he doesn't want to stop the investigation of MediGEN. At a last attempt to stop MediGEN Rieding and Bilderdijk attend a shareholders' meeting. When it leads to nothing, Rieding decides to take up the proposal of Rutger de Klerk and quits as a public prosecutor.

Rieding says farewell to the Unit and leaves with Rutger de Klerk to the US. Govers also takes his dismissal and accepts a job at security company Secu Watch with which he came in contact during his investigation into the death of Harry. Kinky discovers the link between Leenmans & Venhuis and MediGEN. Roberto shadows Jolande de Wit who pays a visit to an adoption office and kidnaps her. Just when Roberto gets her to talk, they are fired at.

Bilderdijk takes control of the Unit during the absence of Sterk and tries to save the Unit. Alexandra goes undercover in private clinic Vita Nova after a patient has been found dead in the woods. Rebecca examines the practices of the new alderman of public scheduling and environment of the Haarlemmermeer, the banker Jeremy Cornwall has died under suspecious circumstances and a colleague of Govers seems have information on the death of Harry.

Alexandra discovers a closed department in Vita nova which is monitored by Secu Watch. Rebecca tries to win the confidence of Mrs Prins and discovers a link between Mellema and the assassinated Karin. Govers searches Mellema house and Sterk and Bildersijk discuss the future of the Unit.

Sterk disciplines Bilderdijk, because he went behind her back. Journalist Remco Haas tells Ruard that the death of an alderman in the haarlemmermeer was a set-up. Toine is arrested on suspicion of the assassination on Harry and Alexandra discovers that Vita Nova is a coverup for an organisation which carries out illegal donor transplantations on African adopted children. The police arrest Irina Breitner. Spalding feels threatened.

The Unit has proved its legitimacy and is not disbanded. In the meantime they try find out who's the big man behind Vita nova, among other things by means of questioning Breitner and the observation of Secu Watch, where Ben Govers is in service of the Unit as informer. Meanwhile the investigation around the situation of the infrastructure plans in the haarlemmermeer is closely watched. The activities of Secu Watch appear not as pure and Ben Govers as informer is discovered.

Koops writes a letter as Breitner with evidence to Bilderdijk and Govers escapes an attack. Breitner has confessed partially, but is now demanding things and the Unit tries trace Toine, who survived a fusillade. The mysterious informant proves to be Mrs Prinsen and without knowledge of her husband, Rebecca and Kinky can obtain important information from the computer of her daughter Karin. Rutger de Klerk wants help the Unit from the IMF. In the meantime Josien sees her relation with Kinky going down the drain due to Alexandra, which has still processing problems as a result of her experiences at Vita nova.

Adrienne Rieding returns from the US, among other things because she wants to experience the resolution of the matter. Van Dalen wants to testify, but by is brought to Koops by bribed keepers, whereupon he assassinates him. The infrastructure plans which the Unit has got hold of by means of the computer of Karin, indicate a criminal network that has already infiltrated the Dutch polics and economy. It does not appear to be possible to find the big man behind the whole organization, because Prinsen, the last hope of the Unit, is assassinated aswell. Eventually the complete story will be printed in a newspaper Article, which was the only wish of Karin.