Sam Ryan recruits the Lyell team to investigate the assassination of the health secretary, but Nikki is unsure whether Sam knows more than she's letting on.

DNA evidence linked to the health secretary’s assassination forces Nikki to face her past in the present. As her investigation progresses, Nikki realises that its consequences will affect her, and her profession, forever.

When a woman confesses to murdering her husband, the Lyell team must determine if all is as it seems. Meanwhile, Simone is shocked to be reunited with a detective from her childhood and struggles to untangle her past.

A secret from his father propels Jack to Belfast. Meanwhile, Simone and Nikki investigate the mystery of a burned body. As familial secrets come to the surface, Jack faces tragedy head on.

The death of an investigative journalist throws the spotlight on to Sam Ryan. Nikki begins to realise that the implications of her discoveries will challenge the principles of forensic science.