When a Bible-teaching mom goes missing from her family's farm, Missouri investigators must decipher a cryptic handwritten note.

When 17-year-old Macin Smith doesn't come home from school, his parents worry. A note hidden in his wallet leaves his family troubled. And police attempt to piece together the puzzle while his family vacillates between hope and despair.

Twenty-one-year-old Kortne Stouffer vanishes from her bed one night following a couple of scuffles with neighbors and friends. Investigators pursue various leads, but the young woman is nowhere to be found, and her family clings to an endless hope.

A young woman moves to the U.S. for a new opportunity, but in a mere matter of weeks, she vanishes without a trace. Kidnapping survivor Elizabeth Smart joins in the search to find her in this mystery where the clues are sparse.

20-year old Bear Diaz has diabetes, leaving him weak and vulnerable. When he vanishes in the night with his TV, backpack and cash, investigators must consider foul play. Then Skylar Tosic disappears, leaving people wondering if the cases are linked.

After a night at home watching movies, 18-year-old Zoe Campos cannot be found by her family the next morning. As investigators pore through the teen's Facebook account, they discover she did not turn in early as her loved ones originally thought.

On route to the airport, nineteen-year-old Katelin Akens makes an unexpected stop at a Virginia shopping mall...and vanishes. Police investigate her loved ones and start to suspect that someone close to Katelin may know more than they’re saying.

Eight-year-old Zachary Bernhardt disappears from his Florida home late at night. Suspicions swirl around his mom, but she denies any involvement and moves away. When another boy goes missing, new theories emerge.

A young man gets life-changing news and drops everything to start a new chapter. But when he never calls home again his family knows something is wrong. Police begin to investigate but encounter a tangled web of contradictory stories.

When 15-yr-old Kayla Berg isn't home after a night out, her loved ones believe she's staying with friends. But when six days pass and the aspiring gymnast is missing, the details of her last known whereabouts raise suspicion in a close-knit town.

Missing Since 2011 from Hartford, Conn. Nineteen-year-old Angel Garcia spends the day riding his dirt bike around Hartford, Conn., but when he never makes it home, his close knit family is thrown into a panic. Angel’s friends tell police that he was chased by a mysterious SUV the night before he disappeared. When detectives learn that Angel had stolen the dirt bike he was riding, they wonder if he was taken out in revenge, or could he have fallen from a railroad bridge into the deep and dark Connecticut River? Finally, four months after he vanished, a clerk says she thinks she’s spotted Angel in a convenience store just 15 miles from his home. Could it really be the missing teen?

Missing since 2015 from Spokane, Wash. Thirty-five-year-old Spokane mother of three, Deanne Hastings never returns home after a late night trip to the grocery store. Though she has a history of mental illness and has gone off the grid for days at a time in the past, her family says she’s always let them know she was leaving. When her fiancé tracks down her abandoned car and finds her purse and phone locked inside, he knows something is very wrong. And as Spokane detectives uncover more information about Deanne’s actions leading up to her disappearance, a slew of theories emerge.