After Meryl and Milly’s search for the legendary Vash the Stampede leads them to an encounter with a dangerous group of bounty hunters, an unlikely hero arrives to save them.

With an entire town after the bounty on his head, Vash must contend with the dangerously destructive Nebraska Brothers - while saving the very same villagers who are bent on bringing him in!

Things get complicated when the gang gets tangled up in the drama surrounding a runaway dancing girl and the son of a caravan owner.

Meryl files a report the Bernadelli Insurance Company, recounting the many exploits, misadventures, and lunatic moments of Vash the Stampede.

A flashback offers a glimpse into the distant past of Vash the Stampede, his brother, Millions Knives, and the enigmatic Rem Saverem.

The greatest battle of Vash the Stampede’s life arrives as he faces-off against Millions Knives. One brother wants to destroy mankind. One brother must stop him at any cost.