Steve becomes embroiled in political intrigue after the murder of a city councilman's wife appears to be part of a larger political strategy. Steve investigates two mayoral candidates, the councilman and the chief of police, as well as a rogue detective and his partner, all with strong motives.

Mark investigates when a teenage girl is murdered after threatening to reveal her affair with her older lover, a newly appointed state Supreme Court Justice.

Nach einem Großbrand wird Jerry Grayle tot aufgefunden. Er scheint erstickt zu sein. Doch dann stellt sich heraus, dass Bauunternehmer Chris Newman Grayle zum Verkauf seines Grundstücks bewegen wollte. Dieser hat sich jedoch geweigert. Dr. Mark Sloan kommt diese Sache komisch vor ...

Larry Dobbs ist ein großer Verehrer von Victoria Larkin, einer der reichsten Frauen der Welt. Als er sich ihr auf einem Empfang nähern will, wird Larkin erstochen, und Larry gerät unter Verdacht. Dr. Sloan entdeckt jedoch, dass Larry Linkshänder ist. Der Täter hingegen muss ein Rechtshänder gewesen sein.

Jesse's new part-time job as trainer of the pro basketball Mustangs turns deadly when he's accused of murdering a star player.

Dr. Sloan investigates a plastic surgeon when an actress's death apparently results from an infection contracted during surgery.

Mark and Amanda are assigned to the task force investigating an airplane crash. An adversarial FBI agent and Russian mobsters make their assignment more difficult.

Steve and Ron lead the chase for the stolen nuclear material.

Rachel, die eine leitende Funktion bei einem bekannten Fernsehsender bekleidet, erleidet im Krankenhaus einen Herzinfarkt und stirbt. Es stellt sich heraus, dass an Rachels Medikamenten etwas manipuliert wurde. Steve und Mark haben gleich mehrere Verdächtige, die für die Tat infrage kämen.

A dead mime leads to an investigation of a crooked auto dealer. Randy Wolfe, a woman who's apparently an expert at everything, leads the investigation while continually annoying Steve.

A motorcycle stunt driver has a fatal accident while filming an action video. Steve investigates.

When Steve is shot and falls into a coma, Mark does all in his power to find the assailant, even threatening a suspect with bodily harm. Mark finds himself the prime suspect when Steve's alleged attacker, Gordon Ganza, is murdered and all clues point directly towards Dr. Sloan.

This episode takes place four months after Mark was convicted of murder. Steve is slowly recovering from his wounds and Mark is still rotting in prison. While Mark endures the taunts of fellow death row inmate Malcolm Trainor, Steve and Tanis Archer launch a rogue investigation to find Ganza's real killers.

A hospital emergeny preparedness drill turns deadly when an unpopular and ambitious nurse is found dead amid the chaos with an eccentric artist the only witness.

A spat between a girl and her boyfriend leads to an apparent murder, leaving the girl and her mother with a dead body, just as dinner guests Mark and Amanda arrive. Panic sets in, when the body disappears, the power goes out, the roads are impassable, and the attacks begin.

A madman charges into a Lamaze class with a bomb, claiming that a fertility doctor was cheating him. Everything is complicated further when said doctor turns up dead.

Ratings seeking stunts by TV talk show hosts Darren & Mary has tragic results.

Kelly, die ein Seminar bei Dr. Mark Sloan besucht, wendet sich Hilfe suchend an den Arzt. Denn sie wird von ihrer Mitschülerin Noelle terrorisiert. Sie hat bereits einige Schüler getötet und hat es nun auf Dr. Sloan abgesehen ...

Dr. Sloan investigates to find out who's behind the death of a driver in a speedway crash.

Ein vierjähriges Mädchen wird mit Erstickungsanfällen ins Krankenhaus eingeliefert. Während Dr. Sloan und Dr. Travis sich darum kümmern, das Mädchen in ein anderes Krankenhaus zu verlegen, stirbt es. Ihre Mutter verklagt daraufhin das Krankenhaus.

The Matthews family is reunited after years apart. Here, Ryan and Tess Matthews come to LA to help Kate when she's in trouble with a con man.

Dr. Travis gets involved in the treacherous and deadly trade of catering when he oversees the annual charity banquet.

Dr. Sloan insists that a man he helped condemn to death for a series of bombings is guilty, even after a post-execution explosion.

Three months after the execution of Lewis Sweeney, explosions are still rocking the LA area every four days. The unpopular Dr. Sloan continues his efforts to nail Carter Sweeney for the bombings.