Martin and Danny are ambushed by Emil Dornvald, who ends up killing the prisoner they are transoprting. Martin is in serious condition, and a barely wounded Danny is at the end of his rope as he tries to find the man who put Martin in the hospital in critical condition. Jack has his hands full with keeping Danny in check and hunting down Emil Dornvald, the mercenary who had previously worked for General Gamba. Things get sticky when Victor Fitzgerald and Tom Banes of Homeland Security get involved, determined to make a deal with Nuru, whom Jack believes isn't the friendly that Homeland Security believes he is.

New York. Una sezione speciale dell'FBI capitanata dall'agente Jack Malone si occupa di persone scomparse, delle quali vengono ricostruite le ultime ore attraverso la ricerca di indizi e informazioni. - di aavv con A.Lapaglia R.Sanchez M.J. Baptiste 2006 USA

The team adds a new member who already as a connection to one of the team as they search for a missing prostitute.

After evidence surfaces suggests that a woman believed murdered by her lover seven years earlier may be alive, Jack wonders if he went too far trying to get a confession.

Wendy Kim goes missing during her shift at the family deli, and the team gets involved to find out what happened to the young Korean woman. It isn't long before they learn that Wendy had recently broken off an engagement to a young Korean man her parents were very supportive of, and that she had recently been doing a lot of on-line dating and had gotten herself involved with the wrong kind of men, including one who wouldn't take no for an answer.

After James Costa is kidnapped after enjoying a night out with his wife in Mexico, Danny and Jack go in at the request of James' mother-in-law, but find that between the Mexican authorities and the grieving wife, no one is too willing to help them. While Vivian, Sam, Martin and Elena work the case back in New York, Jack encounters resistance from the locals, and it is only with Danny's help speaking Spanish that they are able to get much of the information they need. The team soon becomes suspicious of Lucy Costa, convinced she knows more about her husband's disappearance than she is saying.

The team worries about a grieving father who couldn't accept his daughter's death, especially after child pornography is found in his home.

After young Shawn Hopkins disappears one night after leaving the arcade, his parents soon begin to believe that the team is not doing everything to find their daughter, and are shocked to learn that their son has been gambling and has also been seen with a local drug dealer. After learning that Shawn had taken up the cause of a friend who had been raped, Larry and Susan Hopkins are relieved to learn that their son wasn't doing anything wrong, but worried that he still might not come home.

Max Cassidy vanishes after leaving a message on his wife's voicemail, with both Jack and Ann frantic to find him. While investigating, Jack realises that Max was having an affair, and that he's gotten much deeper into a case than he should have following the murder of his partner, Jimmy, a man Max had felt was too green for undercover work. Both Jack and Ann fear the worst as the team tries to hunt down Max.

Sam agrees to do a favor for a friend by looking into the identity of a young amnesiac who was found wearing expensive clothes by two police officers. The investigation leads them to a play the woman was involved in and a mugging gone wrong, then they follow the trail to the woman's past, which seems to have been the trigger for her amnesia. Jack takes some time off work to deal with his father, who is getting worse as his Alzheimers begins to take over and his kidneys fail. Jack finally convinces Frank to seek help, but it's too late, and Jack has to say goodbye to his father.

The team investigates when a young paramedic with gang ties disappears. Jack and Ann bond over their recent losses.

After therapist Gina Hill disappears, the team investigates and initially suspects that one of her patients may be involved. After discussions with Gina's fiancé and her own therapist, the team follows the trail of clues to a bartender named Vince with an unusual ability to get good women to do whatever he wants them to. Martin continues to struggle with his recovery.

When a school teacher goes missing, the team's investigation leads them to suspect that she may have been too closely connected to a student.

After Andy Reynolds, a dishonorably discharged U.S. Marine, goes missing, Jack heads to Tokyo, where Reynolds once confessed to raping a young woman. Back in the U.S., the other agents continue to investigate Reynolds' life, and learn that he had recently gotten the victim to tape a sworn statement that he wasn't the rapist after learning that a former lover had given birth to his child.

When Leah Robinson goes missing after a confrontation with a young man at an art gallery, the team mvoes in to investigate and soon become suspicious of Leah, suspecting her of murdering young women that she believed to be involved with her husband, Ken. Ann isn't quite ready to take her romance with Jack public, and their relationship gets rocky when their different methods of handling the case tip off the suspect.

The team investigates after five-year-old Ethan Heller is carjacked from the family car, and Danny starts to figure out what's going on with Martin.

The team tries to track down a reclusive columnist who hadn't left her apartment in months and was communicating with numerous prisoners.

The team searches for 18-year-old Brandon Parker only to learn that 15-year-old Matt Jameson had stolen his former teammate's identity in order to get a job to support his three younger siblings after his mother had taken off. They manage to connect Matt to an old friend from a former foster home, Casey Miller, and soon realise that Matt has gotten in over his head while trying to keep his younger sisters and brother together. Sam starts to get suspicious of Martin's behavior and confronts him on his drug addiction. She goes to Danny looking for help, but Danny is reluctant to get involved in Martin's problems.

Megan Sullivan is H.I.V. positive, pregnant and missing. Initially the team suspects that her husband, who seemed to be less than thrilled about the baby, is involved, but soon learn that Megan had received a call from a prison, and their search tracks them to a former lover, who gave her H.I.V., her husband's former mistress, who had seen her taking part in a tense conversation not long before she vanished, and her own H.I.V. specialist, who had recently given her bad news. Martin thanks Danny for his help, and tells him that he is continuing to seek counseling for his addiction.

The team searches for a teenage figure skater who disappears after practice one day and discover that many people in her life had reason to worry. The team's investigation leads to the rink's operator, a convicted rapist who was the last to see the girl.

The team searches for Ted Jordano and his teenage children after the three turn up missing and their house is a veritable bloodbath.

Jack finds himself in the hotseat when a young white woman and a young black man, go missing on the same night and Jack is ordered to put more of the team's resources into finding the young woman.

After attorney Jennifer Nichols disappears, the team investigates the last few days in her life and soon find that she had grown disillusioned with her most recent relationship with Allen Davis. Discussions with a married ex-lover reveal that Nichols had recently gone through an old case file relating to a ten-year-old bank robbery, which has a connection to her recent relationship. Jack and Ann avoid discussing a recent development in their relationship -- her pregnancy.