Series Six of The Apprentice was a British reality television series. The series started on BBC One on 6 October 2010 and ran for twelve weekly hour-long episodes, as in all previous years. Following a web-based application, regional auditions and interviews took place during July 2009 in London, Glasgow, Manchester and Birmingham, about 75 candidates were called back for a second round in London and shooting took place in Autumn 2009. There are sixteen participants and the board consists of Alan Sugar, Nick Hewer and Karren Brady. The programme formerly featured Margaret Mountford, who stood down from the role in June 2009. However, she made a guest appearance in Week 11 as an Interviewer.

The series was won by Stella English, a 30-year-old investment banker from London. After winning, English worked at Sugar's company Viglen. Sugar subsequently gave her a new job at YouView in May 2011, after she complained of being "just a glorified PA" in her original position. English resigned from YouView in October 2011, leaving Sugar's employment altogether, claiming that she had had virtually no contact with Sugar in her role. Previous series had begun in March but the 2010 series was postponed until the autumn by the BBC to avoid any issues regarding the general election and Lord Sugar's ties to the then government.