When the wife of a former medical examiner is found murdered, a white powder found at the scene provides the CSIs with a major lead in tracking the killer when it is discovered that the powder is heroin made from human bodies.

While investigating the shooting of a voice coach in an empty theater, Stella realizes that the crime scene is oddly familiar and staged.

When Stella discovers that New Yorkers are being murdered over ancient Greek artifacts, she hands over her badge to follow a clue that leads to Greece and, together with Mac, she uncovers one of the greatest mysteries in history.