Picking up where the season 4 finale left off. The team is investigating the death of a woman named Lauren Santana whom is linked to the bank robbery. She is a friend of Flack's sister Samantha.

Also Mac has escaped the robber but the bodies are still piling up. So the team must quickly find the bank robber before he is able to get away.

A series of deaths from radiation poisoning may be related to a deadly tome in the New York library.

When a supposed air marshal is murdered on a flight to the District of Columbia, Mac searches the plane for the killer and the murder weapon.

The team investigates the puzzling death of a woman named Ann Steele. To solve the case, the team must look for a life size silicone doll. When the team runs into the factory that makes them, it prompts some amusement for some of the team.

Meanwhile, Hawkes meets up with an old college friend who later asks him to compromise some evidence in the case.

The CSI team investigates the shooting death of an archaeologist whose secret life may have caught up to him.

Three drug dealers set to stand trial are found dead in separate places. They were all trying to get rid of witnesses in their crime, but it looks like someone got them first.

The team investigates the brutal murder of a house relocator who was found dead inside a Victorian house that he was about to move from Staten Island to The Upper East Side.

In the one hundredth episode of CSI: NY Mac faces his most deadly foe yet. There is a serial killer loose in New York City killing people with the name Mac Taylor making Mac a target.

A woman is found in the trunk of a crushed car at an auto wrecking yard, the autopsy reveals that she was pregnant, the team needs to find out who she is so they can find the baby.

The team is forced to investigate two crimes at once when a mysterious energy field seems to be the cause of a billionaire's disappearance and the death of his limo driver.

Mac runs into Ella McBride who could cost him time in figuring out if Isabelle Vaughn died by eating the miracle fruit. Stella gets in trouble with Mac while investigating another murder linked to the Greek diplomat that attacked her.

Mac og teamet hans etterforsker drapsgåter i New York. Ved hjelp av den nyeste teknologien innen åstedsgranskning setter de storbyens kjeltringer bak lås og slå. En ung kvinne blir knivstukket og drept under et brudekjolesalg.

Mac finner ulike kroppsdeler som tilhørte en suksessrik brytetrener spredd over hele byen. Saken tar en dramatisk vending når Mac oppdager at det ligger utfordrende bilder av en tolv år gammel gutt lagret på offerets datamaskin. Med en lang liste med mistenkte, går Mac og teamet hans løs på saken.

Faren til en ung jente kommer til New York for å leter etter datteren sin, som han tror jobber som modell i storbyen. Mannen mister livet i jakten på datteren, og Mac oppdager at drapet, samt bortføringen av den unge jenta kan knyttes til en ring som utnytter unge, godtroende jenter. Kommer han til bunns i saken?

Stella, som er til stede på et veldedighetsarrangement, blir like sjokkert som resten av gjestene når verten plutselig svever død i lufta hengende fast i en klase med ballonger. Det som skulle vært et hyggelig arrangement for å samle inn penger til en god sak, blir med ett åsted for drap.

En bilbombe eksploderer i et boligstrøk i New York. En ung kvinne blir funnet død i et av husene, og det viser seg at hun var datter til Felix Redding, som var det opprinnelige målet. Mac har problemer med å finne ut hvorfor Redding er ønsket drept, helt til han oppdager at det utpekte offeret ikke har vært ærlig om hva han egentlig jobber som.

When the wife of a former medical examiner is found murdered, a white powder found at the scene provides the CSIs with a major lead in tracking the killer when it is discovered that the powder is heroin made from human bodies.

When a Native American chief is shot on the subway, the CSIs struggle to translate which one of the several foreign suspects may have caused his death.

While investigating the shooting of a voice coach in an empty theater, Stella realizes that the crime scene is oddly familiar and staged.

When a man falls 20 stories to his death, and his body goes missing after it hits the ground, with no body to process, the CSI's must treat this strange development as a missing persons case.

The most exclusive jewelry auction of the year ends abruptly when an appraiser is killed during the event. The investigation takes an emotional turn when the CSIs must confront one of the greatest tragedies in human history - the Holocaust.

Mac informs an ex-con that he served time for a crime he didn't commit, and Lindsay tells Danny "it's time" for the first CSI baby to be born.

Stella havner i trøbbel med sjefen da hun ikke følger Macs ordre. Han har klart og tydelig bedt henne om ikke å blande seg i etterforskningen av en gruppe som smugler antikviteter fordi hun for personlig knyttet til saken, men Stella klarer ikke holde seg unna. Løser hun gåten på egen hånd?

Et vitne blir eskortert mellom fengselet og rettssalen, men blir kidnappet på veien. Kidnapperne overfaller de to CSI-etterforskerne som passer på vitnet og begge blir alvorlig skadet i angrepet.