Experiment #375 has been activated; a phantom-like experiment that can inhabit and animate inanimate objects. So when it gets loose in the family's house, it inhabits Lilo's toys and creates all sorts of mess, for which Stitch gets the blame. Can they catch the real culprit, or will Stitch be blamed for everything?

It's Lilo's birthday, but no one has remembered. So, she decides to give herself her own party. However, during the day, Experiment #303 is activated and wipes Lilo's, Stitch's and Gantu's memory. Lilo and Gantu, who think they are Martha and Lenny go after Stitch, who has returned to his natural destructive programming, and so they think is a criminal.

Experiment 133: PJ

Lilo's always getting blamed for Mertle's pranks, so she figures it's high-time to pull a few pranks of her own, and what better prank-ee than the mean old substitute hula teacher?

Experiment 210: RETRO

Nani meets some of her friends from high school and tries to impress them by saying she is vice president and they convince her to introduce them to her family. The day only gets worse when experiment 210, tries to revert everyone back to a prehistoric state...

Exxperiment 316: MORPHOLOMEW

(Crossover with American Dragon: Jake Long)

Lilo enters the island's skateboarding competition in an attempt to win the heart of her one and only crush, Keoni. At the same time, Jake, Gramps and Fu Dog visit the island to check out reports that magical creatures - actually Jumba's experiments -- are running rampant.

Experiment 223: Glitch | Jumba automates the house, but an experiment gets into the computer and the house goes crazy! Can Lilo and Stitch save the day?