Senator Harlan Henderson suffers from multiple personalities, and one side of him wants to kill himself. However, he ends up blowing up his secretary, and McGarrett uses handwriting and a diagnosis from a psychiatrist to try to crack the case.

When a psychotic man kills his doctor, Five-O must use a unfinished painting to gather clues to his whereabouts.

McGarrett must prevent a mob war by tracking down an unknown hitman and his intended target.