The "King of Crunk", Lil Jon, guest stars as the captain of the black squad in the first episode of the second season of Wild N' Out. The black squad wins 7 to 5 after winning two of the three games and winning Wild Style. Three 6 Mafia perform their single "Stay Fly".

Today’s special guest is Tyra Banks. Cameron and Mike get a point for doing good in the skit “Couples Counseling”. In the next skit “R&Beef”, the audience picks a theme so the team can create a R&B song. Katt wins that point for the red team for doing the song “The Milkman”. In the Wildstyle game Nick wins it for the red team by asking Tyra to marry him, and she says yes. At the end Sean Paul performs “Temperature”.

Nick Introduces one of the Original Kings of Comedy, Cedric The Entertainer. In the next skit “What Happened Was”, DeRay wins the red team a point. In the second skit Katt Williams and Cedric play “Crystal Ballin’” and The red team wins that point. In the next game “Remix” DJ Wreck asks the audience old song like “The Wheels On The Bus” and the Red Team and Black Team has to make remixes to it. In the game Cedric wins them the point. During the Wild N’ Out game the Red Team takes the belt home.

Episode eatures legendary Rev. Run from Run DMC and a preformance by Young Jeezy and Akon. Games were So Fly were you had to brag about how fly your team captain is, Got Props, and Lift every voice were teams were in gospel robes and had to sing a gospel song about whatever crowd member's problems was.

Destiny's Child member Kelly Rowland appears as the guest star and Ne-Yo sing his hit "So Sick". Games were Talkin' Spit, Who's Your Daddy in which the player immitates a celeberty's son, and Thanks for Nothing Where you immitate an actor winning a award for a movie they should not of been in.

Mike Jones is the Guest doing double duty as the Black Team Captain and preformer. Games are So Fly, R.I.P., and Before and After.

Comedic Legend Charlie Murphy steps up to the challenge to take on Nick in this episode and Busta Rhymes preforms.

Wayne Brady steps back into improve by guest starring in this episode and Paul Wall preforms.

Comedian Mike Epps guest stars in this episode with a preformance from Pitbull.