On the eve of graduation, Wang Yang Ming, who took reversing heart failure as his mission, had a disagreement with his supervisor in medical experiments, and resolutely decided to switch from scientific research to clinical practice, and successfully joined the emergency department of Ruiren Hospital, which ranked first in the country.

Wang Yang Ming's competitive instinct was aroused by his busy life in the emergency department, when he took risks to deal with ventricular fibrillation in the elderly, rescued heat stroke migrant workers, treated stroke patients, and so on, constantly refined his medical skills. At the same time , on the ward formed group named "four masters of emergency medicine" , which Yang's Ming is a part, alongside with Lu Qing Qi, Zu Wen Da and Liu Fei. Now four of them, witness each other's growth and change, gain friendship and love, and experience dispersion and separation on their ward.