Brain hatches a plot to hypnotize people, but he needs white crab meat to succeed. In order to get the crab meat, he takes a submarine to the wreck of the Titanic. Unfortunately, the CIA spots his sub and orders its destruction.

Brain hat die Idee Beiträge zu einer Berufsgenossenschaft zu sammeln, um einen neuen Plan zur Eroberung der Weltherrschaft zu finanzieren.

Brain verwandelt Pinky in ein Ungeheuer, um die Weltherrschaft zu erringen.

Brain konstruiert eine Maschine, um Pinky intelligent zu machen. Dadurch wird Pinky aber plötzlich klüger als Brain.

Pinky und Brain beschreiben in einem Lied die einzelnen Bereiche des Gehirns und seine Funktionen.

Brain versucht mit hypnotisierender Stimme über das Radio die Weltherrschaft zu erobern. Die Mäuse scheitern aber schon im Radiostudio.

Pinky singt über Käse.

Um ihren neuesten Plan zu finanzieren, gründen Pinky und Brain einen Scheinstaat, der massive Zahlungen von der UN Entwicklungshilfe bekommen soll.

Brain versucht die Weltherrschaft an sich zu reißen, indem er die Hauptrolle in einer Sitcom übernimmt, doch sein Traum von Ruhm und weltweiter Dominanz geht schnell in die Brüche.

Pinky und Brain gehen auf Zeitreise ins Paris des 18. Jahrhunderts. Während Napoleons Siegesfeier wollen sie eine Ablenkung inszenieren - leider werden sie selbst zum Ablenkungsmanöver...

Pinky and the Brain head to the North Pole. Pinky just wants to see Santa, but the Brain has a more sinister plan. He wants pretend to be an elf so that he can mass produce a hypnotic doll named "Noddle Noggin" in Santa's workshop. He then hopes that Santa will distribute the toy all over world so he can take over.

Brain comes face to face with his former friend and now enemy, Snowball. And it seems Snowball has his own plans to take over the world.

In Victorian England, the Brain realizes that he can take over the world by becoming president of the "Pompous Explorers Club". since the position usually leads to the Prime Ministership of England. In order to become president of the club, he must make it around the world in seventy-nine days.

Brain plans to melt the ice caps with the Hubble Space Telescope once he buys everything higher than the 39th floor.

Brain hopes to take over the world by convincing everyone that Abraham Lincoln has been reincarnated. He takes up ventriloquism and plans on using a statue.

Brain tells a group of mice the story of "Don Cerebro" a mouse driven by his dream to take over the world.

Pinky searches for the Brain in post-World War II Vienna. He misunderstands people when they try to tell him the Brain is dead and his misunderstandings lead to a series of misadventures.

The Brain captures two mice for an experiment to aid in a plan for world domination. He discovers however that the two mice are his parents.