"Gunsmoke," "Bonanza," "The Rifleman," "Wild Wild West," "Maverick," "Big Valley," and "Daniel Boone" are among the iconic series profiled in this episode.

This star-packed episode features fresh interviews with Jerry Seinfeld, Roseanne Barr, Tim Allen, Ray Romano, and Bob Newhart; revealing how America's top stand-up comics made the transition to the sitcom form.

Following the legacy of the sitcom stars who followed, including Mary Tyler Moore, Betty White, and Marla Gibbs.

The four formative sitcoms that shaped the TV landscape: "I Love Lucy," "The Honeymooners," "The Andy Griffith Show," and "The Dick Van Dyke Show."

The fascinating back stories of "Star Trek," "Lost in Space," and "Twilight Zone" are told and packed with fresh insights on the stars who made these series such a long-term success.