Staffel 1 von Brotherhood wurde am 9. Juli 2006 erstausgestrahlt.

Michael returns home after seven years on the run and reestablishes his criminal empire. Tommy tries to stay on the straight and narrow while representing his district. Eileen cheats on her husband and descends into drug addiction.

Staffel 2 von Brotherhood wurde am 30. September 2007 erstausgestrahlt.

Michael struggles to recover from a brutal beating while consolidating his power. Tommy maneuvers to win reelection as he distances himself from his brother's criminal activities. Rose sows unrest between her sons.

Staffel 3 von Brotherhood wurde am 2. November 2008 erstausgestrahlt.

Michael tries to avoid being whacked when his nemesis is released from prison. Tommy gets passed over for the House speakership and must rebuild his political career. Rose's health deteriorates.