A father finds his son dead, having taken a drug overdose. Knowing this will affect his wife he decides to report it as an accidental drowning. Quincy's friend Volmer is the local coroner and politics lead to him not being able to autopsy the boy. He asks Quincy to help him out.

If that was not enough he also has to deal with a textile mill boss who refuses to fix irregularities at work and when an accident happens wants to hide the truth.

Sam tries to persuade the authorities to take notice of a new process he has developed to help track down killers. His tooth print process shows that the man the police have as their suspect in a rape case is not the man who did it. The bite mark has to have come from another person. His process being unknown though means that it is not accepted or believed.

Quincy becomes concerned when a medical student accuses a veteran staff doctor of covering up the causes of a homicide while doing an autopsy.

Mr. & Mrs. Estes have baby twins and with Bill Estes working all day Madeline is finding it harder and harder to look after the two boys. One night one of the twins dies suddenly in its sleep. All the medical and police personnel involved thinks that the baby died from SID (Sudden Infant Death) Syndrome, but a new, young and ambitious ME, Dr. Gauge, thinks that it was battered and calls in Lt. Monahan.

Bill, remembering how his wife was getting angry with the workload of looking after both babies begins to think that she could have killed their son.

When a potential Olympic champion is cut down in his prime his coach is accused of negligent homicide. A young lawyer, the only man who is willing to defend him, must rely on Quincy to find evidence to clear his clients' name.

Quincy rushes to an Arizona Native American reservation when he hears that his foster son, Chester, is suffering from bubonic plague. When he confirms this and tries to warn the local authorities he finds that they have no interest in the potential disaster. They are much more concerned with the forthcoming opening of a new country club that will bring tourists to the area. They have a big golf competition planned with many big names arriving and they don't want to cause a panic that would ruin the resort before it has even opened.

Quincy is hired as a technical director for a movie that is recreating a famous homicide case. Watching the murder scene being filmed convinces him that the real murderer is still loose and that the woman in jail for the crime was innocent. He sets out to find the truth but is hampered by the reluctance of the woman convicted to get involved. She only has a few months now until her parole hearing and if she is still trying to prove her innocence she has no chance of getting out if Quincy fails to find the real killer.

The smuggling of Nazi-held gems from Cairo to Los Angeles in an Egyptian mummy leaves several corpses in its wake.

A narcotics officer comes under investigation by the IAD when drugs kill an airline stewardess he knew, and sometimes used for information.

Quincy investigates a plane crash at sea and discovers that most of the victims died needlessly.

When Quincy sits on a jury for a homicide case he realizes that there are errors in the evidence, which could lead to the conviction of an innocent man. Not being one to sit by without doing anything he is soon causing uproar in the court with his constant questioning and interrupting.

Polly Carmody, a young 9 year old girl, is murdered and found in a refuse bin. The police quickly pick up a suspect but Lt. Alex Markasian thinks that he doesn't fit the profile of a child murderer. He is much more interested in the fact that the 'father' of Polly is in fact her stepfather, and has only been in the house for a couple of months. When the arrested suspects blood type doesn't match the blood found on the victioms clothing Donald Thompson, the stepfather, becomes an even more likely suspect. This is made even more likely when Alex and Quincy discover some disturbing things in Thompsons' background.

A young boy, Jeffrey, dies when he falls from a building, after being chased in there. After the autopsy a doctor turns up wanting to have the brain. Jeffrey had Tourette's Syndrome and the doctor wants to try and find out what causes it and how to cure it. This is the only way he can research it as the drug companies don't think they could make enough money to make it worth their while.

A club near Danny's burns down killing the owner, Lou Chesler. His wife, Elizabeth, is suspected of causing her husband's death, especially by an insurance investigator for the company that held her husbands' life assurance policy. He thinks she has also killed previous men in her life and warns the latest one that he could be next. The latest one is, of course, Quincy.

An explosion kills a man who is discovered to be the advance scout for a hitman. Quincy is in a race against time to find the assassin and thwart the plot to kill a government official at a hotel convention.

Quincy does battle, on a live TV show, with the author of a diet book when he discovers that a model that used it has died. His outspoken statements against the book lead to him, and the department, being sued by the author.

A group of concerned citizens patrol their neighborhood to help keep crime off the streets. After chasing an armed criminal into a warehouse a gun battle takes place and they shoot the man. When examining the body Quincy proves he hadn't fired a gun and was so drunk he couldn't even have stood up at the time. He was not, and could not have been the thief they chased into the building. The vigilantes now look as if they are going to be charged with murder, will Quincy be able to help them?