Many of the town's citizens suffer from food poisoning. Police officers investigate and find out that the cause are poisoned apples sold by the Di Giacomos, a family of farmers. After some interrogations by Captain Anceschi, it seems that the family is not responsible for the case after all. Don Matteo's investigations lead him to a seasonal worker Di Giacomo's who seems to have motive.

A young soccer player dies of a drug overdose. Was it an accident or murder? The first person suspected by police officers is the owner of a tattoo shop who was in trouble with drug abuse before. The woman denies to be involved and Don Matteo tries to convince the police.

Nino Coronna is found in a garden of a villa, next to a corpse. The victim is the owner of the house, Giulia Chimenti's husband. Nino seems to be guilty and is immediately accused of homicide. Maresciallo Cecchini has to investigate alone because Captain Anceschi is a 'special friend' of Giulia. When Anceschi seems to be involved in the homicide, Don Matteo and Cecchini have to uncover the truth.

Monica, who believes to have cancer, meets the healer and magician Kaspar, who has a reputation of taking advantage of people in distress. After several healing sessions with Kaspar, Monica's medical condition improves. It's a miracle - and attracts many people to Kaspar's 'practice'. Police officers question Kaspar, but only Don Matteo's help leads them on the right track

A famous chef is killed. Police suspect the Bagnetti brothers, who were evicted by the chef and therefore have a motive. Gerolamo, a homeless man and witness of the homicide accuses Mordelli, another famous chef. Don Matteo thinks that the police in on the wrong track.

Maresciallo Cecchini is suspected to be a drug dealer! He supposedly only keeps his position as police officer to cover up his life of crime. Don Matteo and Captain Anceschi have to prove their friend's innocence.

Don Matteo is on a bus trip when a rich elderly lady is given a fatal shove. Don Matteo watches the scene but is too far away to recognize the guilty. Police investigations lead to the victim's nephew, who sold merchandise on the bus. Don Matteo finds out that the nephew is interested in more than just the inheritance.

A young boxer dies during training. Accident or homicide? The boy's trainer is accused of the crime. Don Matteo tries to solve the riddle.

A well known businessman is kidnapped. Who organized the abduction? Police seem to be on the right track and arrest an employee of the victim. While the son takes over his father’s business, Don Matteo finds out that many of the employees have bad interests…

Tarek, an immigrant, wants to traditionally arrange a wedding for his sons, who disagree with this tradition. To avoid the marriage, Mohammed commits a theft. When his brother Abdul gets involved in a violent crime, Don Matteo begins to investigate.

Sergio is run over by a car. His fiancée Angela mourns his death but decides to begin a new life. After joining a music band, she receives anonymous threats: Someone wants her to leave town. Police investigations lead to a young man who seems to be involved in the car accident. Don Matteo has to solve the case.

During a religious procession, Benito Lippi is bitten by a snake. Only an antidote can help to save his life, but it is hard to find since the snake is of a rare Asiatic breed. While police investigate who smuggled the snake into the country, suspicion falls on an oriental man who was seen near the victim during the procession.

During a walk in the woods, Nerino falls into a 'hole' and discovers an old Etruscan tomb, filled with treasures. When police officers arrive, the treasures have disappeared. Suspicion falls on Lanza, a surly man who was involved in a robbery before. But Don Matteo suspects a certain Mr. Todi.

A fire threatens the town. The culprit seems to be a little boy, Fabio, who immediately admits to be guilty. His father is convinced of his innocence and asks Don Matteo for help. It seems that the boy wanted to get his father's attention.

A young woman is killed in her home. Natalina, the house keeper, can aid police investigations because she saw Giovanni Antonelli escaping from the house. The man admits that he had a relationship with the victim but refuses to confess to the crime. Police investigations move to a company, owned by the victim's 'real' boyfriend.