Crossing more than 10 years in their career, they start to face that era where they reach various roads to walk on, their work, and their private lives. Aizawa Kousaku left the lifesaving center of Shoyo University Hokubu Hospital, devoting himself as a brain surgeon aiming high to perform operations every day. Shiraishi Megumi, due to the insufficient aide in the Shohoku lifesaving center now is struggling as the leader of the flight doctor staff. Once with them in aiming to be a flight doctor, Hiyama Mihoko left Shohoku Hospital and is now an obstetrician and gynecologist in a perinatal care center. Saejima Haruka even now continues to be an ace flight nurse. And Fujikawa Kazuo, together with Shiraishi supports Shohoku lifesaving, has become a lifesaving doctor with specialization on orthopedic surgery.

One week has passed since Aizawa Kousakuhas returned to the Emerg ency Lifesaving Center. However, his guiding principles towards the interns clash with Shiraishi Megumi that Hiyama Mihoko and Fujikawa Kazuo are at the point of getting fed up. Shiraishi is having difficulty in acknowledging Aizawa's strict supervision of Yokomine Akari and wants the center to return to its smoothness. She quickly starts to regret wishing Aizawa's return.

"Life and the thing that person thinks is more important than life. Which of it when the time comes that you have to choose, what will you do?" Aizawa Kousaku faces this problem.

Aizawa Kousaku receives information from Shinkai Hiroki that due to convulsion attacks, Amano Kanade has been admitted. Shinkai conveyed this when Kanade was talking to Aizawa. Even with Kanade being in this condition, she still doesn't want to accept surgery. Shinkai expects Aizawa's persuation. However, no matter how Aizawa calls out to Kanade, it's still uncertain.

With Amano Kanade's emergency operation and supporting another patient's sudden change in condition althrough the night, Aizawa Kousaku is unusually completely exhausted at their medical office. There, Fujikawa Kazuo carries in his arms a box of tomatoes as he reports for work. It's the tomato that the pregnant Saejima Haruka can only eat. Fujikawa complains that Saejima does not accept other food and if there's no tomato she gets in a bad mood but he looks happy in saying so. Hiyama Mihoko consults Shiraishi Megumi on the case of a guy you worry about having a wife but hides it under a story of a friend. However, with Shiraishi answering in a loud voice don't go into adultery, the other party Hiyama's consulting was mistakened and regrets it.

Because of Aizawa Kousaku and Shinkai Hiroki (Ando Masanobu), Amano Kanade's surgery safely ended. However, when Shiraishi Megumi asks Shinkai about it, the enunciation was quite bad. Kanade's parents seem to understand the result of the surgery however... On the other hand, a 17 year old high school male student has been given a diagnosis of brain death. That implies to Tachibana Keisuke that the potential heart transplant for his son Yuusuke has probably come. With cardiovascular doctor Inoue Nobuaki's identification, Tachibana reins himself not to hold expectations.

Aizawa Kousaku visits the office of department head Saijou Akira (Sugimoto Tetta) and conveys his withdrawal as candidate for the Toronto University residency. Asked by Saijou if the cause is Amano Kanade's postoperative progress, Aizawa goes out of the room with no particular reason. Shinkai Hiroki then arrives and gets surprised hearing from Saijou about Aizawa's withdrawal.

Aizawa Kousaku tried to distance himself from the affairs of Amano Kanade's rehabilitation but even if he turns the other way, he rather hears Kanade's voice. That day is also the first day Haitani Shunpei resumes to work in lifesaving after being injured from falling of a train platform. Haitani's explanation of the fall from the platform was due to the effect of the sleeping medication but Shirashi Megumi and company suspects if it was suicide. Haitani perceiving such atmosphere, goes on normally but Shirashi and Fujikawa Kazuo too has become awkward.

Three people with emergency cases are brought in the 1st ER. One person is Morozumi Kohei, a 33 year old wheelchair rugby player. While warming-up during half time, wheelchair seems to have fallen down from stairs. Furthermore, there's a burn patient, and a patient who fell from a high altitude, all the 3 of them were brought in. Aizawa Kousaku gathers everyone's strength and with swift correspondense, the result is, 3 people's lives weren't lost and have been moved to the ICU. As Tachibana Keisuke thinks back upon months ago, he talks how Shiraishi Megumi has come to lead a good team. In the medical office, Natori Souma's father, Shouma was waiting. What is his father's purpose?