Un an après la mort de son amoureux, Emmanuelle St-Cyr, cheffe de l’urgence de l’Hôpital St-Vincent, invite ses meilleurs amis pour son anniversaire. Quelques jours plus tard, à l’hôpital, Emmanuelle accueille dans son équipe Jacob Faubert, un jeune urgentiste. Les ambulanciers arrivent avec deux ados grièvement blessés. Pour sa part, Philippe évalue Chrystelle, une jeune femme en proie à d’inquiétantes hallucinations.

Chrystelle et son conjoint Jonathan donnent du fil à retordre à l'équipe de l'urgence. On s'inquiète pour Sophia dans les circonstances. Depuis le souper d'anniversaire, Delphine craint que Philippe ne la quitte. Éric s'occupe de Martin un itinérant en état d'ébriété prononcé. Emmanuelle profite de la présence de l'inspecteur Fortin pour le relancer sur l'enquête qui a suivi la mort de son amoureux.

Emmanuelle reçoit des confidences de Daniel puis de Philippe sur leur vie de couple. L'équipe est mobilisée pour accueillir le joueur de tennis étoile Michael Roy qui s'est gravement coupé le pouce. Son père et entraîneur est à la fois très inquiet mais aussi très exigeant envers le personnel. La mère de Jacob, la psychiatre Julie Faubert, se présente pour faire la deuxième évaluation de Chrystelle. Emmanuelle insiste pour la rencontrer.

Michael Roy converse avec Éric. Alors qu'Isabelle s'apprête à quitter pour aller chercher son fils à l'école, Emmanuelle lui demande de rester pour une intervention d'urgence. Delphine, qui traverse une mauvaise passe, encourage Chrystelle en lui disant qu'elle est bien placée pour comprendre son désarroi. Très inquiet pour sa blonde, Philippe demande à Emmanuelle de faire quelque chose.

Emmanuelle révèle à Jacob ses trucs pour fonctionner lorsqu’on perd un patient ou une patiente. Elle lui demande ensuite de s’occuper d’un homme qui se présente avec une drôle de blessure. Par ailleurs, elle constate certaines séquelles de la blessure d’Aiden et en discute avec sa mère. À la fin de la journée, les amis se retrouvent chez Emmanuelle pour un souper bien arrosé.

Lundi matin, Marco raconte à Jacob la nuit particulièrement agitée qu'il a passée à l'urgence. Pendant la réunion hebdomadaire, on fait le point sur l'évolution des cas de Chrystelle, Aiden et Michaël Roy. Audrey fait remarquer que la liste de matériel défectueux ne cesse de s'allonger. Jacob s'occupe de Mélodie, une jeune femme qui semble s'être cassé le poignet en tombant.

Emmanuelle explique à Aiden certaines conséquences de sa blessure à la tête. Comme chaque semaine, Éric fait la tournée pour trouver des partenaires pour acheter un billet de groupe pour le gros lot. Philippe a une bonne conversation avec Chrystelle, qui prend du mieux.

Delphine remarque un froid entre Isabelle et Emmanuelle. Elle fait part à Jacob de ses inquiétudes concernant Michaël Roy. Emmanuelle profite des résultats des tests de Mélodie pour servir une autre leçon à Jacob. Pascal reçoit la PDG Mylène Lapierre dans son bureau. Il entend lui parler des problèmes avec le matériel.

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Philippe raconte à Pascal la première journée du procès de Dominic Lord. Francis est surpris d’apprendre qui est Rosalie. Delphine revoit son ami Guillaume pour lui parler de ses problèmes de santé. Emmanuelle prend en charge Camille, une femme de 35 ans qui souffre d’anorexie.

Emmanuelle accueille les parents de Camille; Philippe réconforte Delphine; il discute avec Camille, qui est dans le déni total; Mélodie revoit le Dr Labrie.

Emmanuelle se fait taquiner en réunion parce qu'elle est devenue une vedette des antivax sur les réseaux sociaux à cause d'un malentendu à propos de son traitement expérimental sur Marilyn.

Emmanuelle informe Pascal des derniers développements dans le procès de Dominic Lord; elle annonce à Rachel que l'on va bientôt savoir si Marilyn répond au traitement expérimental.

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