Fortysomething is a 2003 British comedy-drama series, starring and directed by Hugh Laurie as Paul Slippery, a doctor facing a mid-life crisis. His wife Estelle is starting a new career as a headhunter. His three sons, Rory, a student at the fictitious University of Reigate, Daniel and Edwin, are sex-obsessed. Meanwhile, Paul appears to hear the inner thoughts of others.

Other important characters include Paul's colleague and nemesis, Dr. Ronnie Pilfrey, and Estelle's new employer, Gwendolen Hartley.

The series was written by Nigel Williams based on his 1999 novel of the same name. The six episodes of the series were broadcast on ITV. Although a ratings failure on first transmission, leading to it being moved to an off-peak timeslot midway through the run, the appearance of several actors who went on to greater fame has subsequently led the series to sell well on DVD.