From its 1943 origins to today's microdosing trend, LSD has been expanding minds and changing lives with the help of counterculture gurus — and the CIA.

Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, have recently become the subject of scientific studies exploring their potential to treat mental illness.

Championed by both therapists and ravers, ecstasy stands out as the first psychedelic likely to be approved by the FDA as medicine, thanks to passionate advocates and its value as a treatment for PTSD.

Mescaline is the psychoactive molecule found in San Pedro and peyote cacti. Native Americans have had to fight for legal access to these traditional sacred medicines and take them in religious ceremonies, experiencing powerful healing from struggles like addictions and trauma.