Three test subjects of an elaborate experiment start experiencing strange symptoms and turn to geneticist Dr. Alex Sarkov for help.

In hopes of finding Sarkov, the Imperfects look for another Wellness Program participant while dealing with the fallout from their new powers.

The search for Sarkov leads Juan, Abbi and Tilda into a seriously messed up situation. A mysterious woman begins to zero in on her targets.

While Juan reconnects with family, Abbi and Tilda meet another test subject with powers of his own. Investigators start to hunt for the Imperfects.

Abbi, Juan and Tilda investigate an attack after a mutant strikes. Sarkov inches closer to a cure, while Burke has a breakthrough.