As the MPU moves into new offices, which comes with new boss Inspector Hollis Braun, a call comes in reporting the disappearance of an entire city bus full of students on a field trip. The team utilizes a father who tried to stop the kidnapping, as Jason reaches out to an old colleague for assistance in the search.

The MPU searches for a Benjamin Franklin aficionado after he suspiciously disappears during one of his city tours. Meanwhile, a new forensic scientist is hired and the team attempts to manage her over-eager working style. Jason and Mike try to bond as new partners.

A young pregnant woman goes missing one day before her emergency c-section and the adopting mother turns to the MPU to locate her before the baby's life is risked. Meanwhile Jason digs deeper in the car bombing case and meets a disapproving Braun.

The MPU searches for a homeless female teen that disappeared after running away from home and living in Philly's Gayborhood. Kemi is hit especially hard as the team races to find and rescue the missing teen. Jason and Nikki spar over his continued investigation into the car bombing.

The MPU searches for a kidnapped tough-as-nails neighborhood watch captain. Jason enlists Wayne's help investigating the car bombing. Mike is concerned Nikki is keeping secrets from him.

Mike is taken back to his first unsolved case when the remains of an Amish man surface seven years after his murder. After he reconnects with the man's family, the wife of the man mysteriously goes missing, prompting a massive search and disclosing a web of deceit.

A popular travel influencer goes missing and the MPU race to find her as a hurricane rages and a state of emergency is declared. Mike and Wayne get closer as Helen connects with someone unexpectedly in the aftermath of Nikki's bachelorette party.

The MPU is on the case when a young hockey player goes missing during a fight with an opponent on the ice. Kemi is unexpectedly reunited with a face from the past. Nikki runs interference with Braun when Jason dives deeper into the car bombing murders.

The MPU is on the case when a young boy claims his father was abducted by aliens as they were stargazing at a remote campsite. Jason and Nikki enlist Mike's help in getting access to Braun's computer files. Kemi and Helen partner up and venture out into the field.