Bienvenue à Jerusalem's Lot en Nouvelle-Angleterre, communément appelé Salem's Lot. Nombre d'habitants : 1319. Mais depuis qu'un intrus bizarre a fait son apparition dans la maison hantée, Marsten House, et qu'un acte de cruauté indicible tourmente le paisible village, plus personne ne s'y sent vraiment le bienvenu... ou même en sécurité. Dans cette nouvelle interprétation poignante du terrifiant best-seller de Stephen King. Rob Lowe incarne l'auteur Ben Mears. Après une longue période d’absence, Mears retourne dans son village natal pour y affronter les démons de son passé. Mais dans ce petit village paisible, les apparences sont trompeuses. Un embrouillamini de mensonges et de tromperies a ouvert les portes de l'enfer, et l'écrivain tourmenté doit mener un combat contre un mal qui n’a pas de nom.

On the surface, Jerusalem's Lot appears to be a picture-perfect small town, right out of a Norman Rockwell painting. But there is something evil festering in this Maine hamlet, and it seems to be emanating from the ominous Marsten House. Ben Mears returns to Salem's Lot to wrestle with the demons of his past by writing a book about the town and its inhabitants. As a child, Ben had a horrifying experience in the house that left him emotionally scarred. But Ben soon discovers that he is not the only newcomer to town. An antique dealer named Richard Straker has also arrived to open up a new shop with his silent partner, Kurt Barlow. Before long, strange things begin to happen. A series of mysterious deaths and disappearances eventually lead Ben, waitress Susan Norton, high school teacher Matt Burke and Father Donald Callahan on a quest to uncover the terrifying truth. What they find challenges their notions about the nature of evil, as horrors both human and inhuman threaten to destroy the town's way of life.