Brennan is about to go out for dinner with her old professor and ex-lover when Booth asks her and her team to help identify the remains of a young woman found in a refrigerator.

Booth and Brennan investigate when a dug up corpse is found in the back of a gang member's car. While being questioned, a drive-by shooting allows him to escape. Booth and Brennan follow the clues, which lead them to an empty grave and another body in a grave at a wealthy senator's house, where the gang member used to work.

The team helps Deputy Director Sam Cullen's daughter, Amy, when she contracts a rare form of lung cancer after receiving a bone graft. Booth and Brennan learn she is not the only victim with this rare form of cancer.

When the body of a young man, who's been missing for nearly three weeks, is discovered, the investigation leads them to his girlfriend, who is a foster child. Bones becomes emotionally involved in the case since, she too, became a foster child after her parents disappeared.