Booth and Brennan investigate the death of Terence Bancroft, one of the Jeffersonian's major donors, found dead at his home. Hodgins' relationship with the wife of the deceased years earlier, compromises the case.

When Angela draws the face of an old woman to go with the decomposed skeleton of someone much younger, they soon learn the victim had Progeria, an aging disease. Booth and Brennan investigate to discover who would want to kill such a fragile person. Meanwhile, Hodgins and Angela's walk down the aisle doesn't go as planned.

After a skull smashes into the windshield of a teenager's car, the investigation reveals the skull has been gnawed on by human teeth, which implies cannibalism and marks the beginning of the Widow's Son case. Meanwhile, Angela and Hodgins hire a private investigator to find her husband. Bones searches for Zach's replacement and the team gets a wonderful surprise.

On Halloween, two mummified bodies are discovered and found to be people reported missing the past two Halloweens. When Booth and Bones learn about a missing girl, linked to the suspect of the previous murders, the race is on to save her life.

After the body of an archbishop is found, missing the kneecaps, the team concludes the murder is related to the Widow's Son case.

All team members are working to identify the bones from a college athlete who suffered a lot of fractures. After the body is identified they talk to his sister and somebody who acted as a sort of an adviser for the deceased. Angela and Hodgins have an important talk. Zack is overwhelmed by having to reconstruct the crushed bones to form a skeleton.

A woman's car is run off the road and she is killed, but her baby miraculously survives the accident. Booth and Brennan go to the woman's hometown to try to find out who's responsible for running her car off the road. Bones, with help from Booth, takes care of the baby until the team finds out who killed the mother.