After a winter abroad, Hank returns to the Hamptons to celebrate the latest addition to the HankMed family. Evan and Paige take a hands-on approach to their marriage. Later Evan hatches a plan to make Hank stay in town after a saxophone player falls ill. Meanwhile Divya experiences the joys of motherhood and a mysterious party guest brings surprising news for the Lawson family.

Hank, Evan and Paige try to help Eddie have a relationship with Emma; Hank treats a private investigator; Divya must find a nanny; Jeremiah makes a friend.

Hank becomes embroiled in a plot while in Monte Carlo; Divya and Jeremiah treat mysteriously ailing firemen; Paige and Evan search for a new place to live.

Evan reaches out to a woman with a strange illness; Paige and Russel have a realization about their client; Evan and Jeremiah recognize they will have to go to battle; Hank wins back a former patient.

Jeremiah und Evan machen sich Sorgen, keine erschwinglichen Räumlichkeiten für das HankMed-Labor finden zu können. Da bietet ihnen Ray Mazzarino ein Objekt an, das eigentlich perfekt geeignet wäre – wenn es da nicht einen Haken gäbe. Unterdessen behandelt Hank den begnadeten Koch Franklin, der sich bei den Vorbereitungen auf die Eröffnung von Rays Restaurant verletzt hat. Ray vermutet, dass Alkohol im Spiel war, was Franklin vehement abstreitet. Als es aber zu einem weiteren Vorfall kommt und der Küchenchef zu guter Letzt auf den Tischen tanzt, wird Hank misstrauisch. Divya behandelt den Vater einer sehr talentierten Rennfahrerin, der während eines Rennens zusammenbricht. Außerdem fasst sie ihrer kleinen Tochter Sashi zuliebe einen Entschluss. 

Hank and Divya treat a house-sitter; Jeremiah treats a burlesque dancer and gets close to her roommate; Paige makes an important discovery; Emma becomes a tipster for a gossip site.

As a new mother, Divya finds herself bonding with a HankMed patient who is struggling to get pregnant. Hank reignites his romance with a woman he met in Europe when she arrives in the Hamptons, and Divya worries about Jeremiah’s relationship with Viviana. Emma is the new it-girl on SnarkHampton and gets invited to one of the hottest parties of the summer, and Paige and Evan enlist Bob to help with their issues with Russel.

Hank treats a perfumer who is losing the sense of smell; Evan and Ray hold a grand opening for HankLab; Divya tries to protect Jeremiah.

Hank and Boris meet a potential trial patient in Argentina; Divya meets Sashi's grandmother; Russel tries to make amends with Paige; Evan strives to expose Oz.

Despite their strained relationship, Divya and Jeremiah work together to treat a model who is struggling to eat. After Ray’s past catches up with him, Evan tries to distance himself from their partnership but it proves to be harder than he expected. Hank and Boris return from Argentina with an idea to enlarge the scope of Boris’ foundation, and Emma violates her brothers’ trust.

Hank treats Cinco when his sore wrist turns out to be more complicated than a simple sprain. Evan and Paige help Emma set a trap to catch Oz. Divya and Jeremiah treat a boat-builder who resents being left behind when his business partner takes a job sailing around the world. Hank helps Charlotte adjust to regaining her vision but the learning curve is steeper than either of them anticipated. Meanwhile, Boris takes a major step towards expanding his foundation.

Hank and Evan search for Emma; Evan cannot understand Hank's reluctance to join Boris' new endeavor; Paige and Evan learn something about Bob; Jeremiah tries to accept Viviana's changes.