In the series debut, housewife Nancy Botwin struggles to deal with the sudden death of her husband, while her best friend and neighbour Celia Hodes learns a devastating secret when she tries to catch her daughter in the act with Nancy's son.

As Celia deals with the other woman in her marriage, Nancy contemplates creating an enterprise to solve the cash-only financial issues caused by her drug dealing. Silas has to come to terms with his girlfriend's sudden departure, while Shane tries to come to terms with missing his Dad.

A mountain lion is on the prowl in Agrestic, but it's the medical marijuana facility that is causing the most havoc in Nancy's life. Faced with the dilemma of having to compete, Nancy has to get cooking. Silas makes a move on Megan causing him some colourful problems of his own and Celia and Isabel's war over weight issues gets dirty.

Nancy gets a rude awakening when her brother-in-law Andy comes for a surprise visit. Doug has an idea for a location for the faux bakery, which Nancy may need more than ever with Andy in the way. While Andy wreaks havoc in the Botwins' lives, Nancy is introduced to "The Candy Man" in order to help meet her customers' needs, and Celia drops a bomb.

Nancy gets a reality check about what a life of crime can entail. Andy acts like a fool and gets arrested. Celia tries alternative methods to deal with her breast cancer. She also steps out of her box and bonds with children. Shane gets in trouble at school. Again.

Nancy attempt to play around in an effort to relieve some stress. Nancy, Celia, and Conrad go out to a club where Celia and Conrad "snuggle up." Meanwhile Andy meets a woman who he lies to like he would anyone else and Lupita starts investigating so as to gain the upper hand in her employee/employer relationship.

Nancy hires an employee, and becomes known to a rival in the process. Shane makes a new friend, and Andy gets to know the new friend's mother. Celia's mother comes to visit after Celia's surgery.

Uncle Andy acts foolish at a ceremony for Judah. Shane gets in trouble again. Celia and Dean duke it out. Nancy finds out who it is that has been "delivering" pennies onto her car and fountain and she deals with them. Andy and Doug team up to bring more trouble into Nancy's home while trying to flush out the infestation of a rat. Nancy turns down an interested single father. And Uncle Andy exposes too much of himself yet again.

Isabelle experiments, Andy gets drafted, Peter may not be who Nancy thinks he is, Silas gets high, and Nancy cuts out the middleman.