Jackie steals Dr. Roman's DEA number. Coop is recruited by a 'sperm scout.'

Coop learns his sperm count is too low for donation; Carrie gets a lucky break; Akalitus' poker habit pays off; Grace drops a bomb on Jackie.

Jackie goes off the deep end; Frank discloses a secret about his past.

Frank searches Jackie's house for drugs, but she removes them in time and hides her stash in a ladies room at the hospital. Later, Jackie bonds with a homeless, alcoholic nun; and finds comfort in the arms of a fellow drug user. Meanwhile, Zoey confronts Prentiss about his dissatisfaction and encourages him to do what he loves.

Jackie's fake identity is compromised when it's learned that Carrie's DEA number has been stolen by a woman named Nancy Wood. Meanwhile, Jackie worries about her dwindling bank account and lack of pills; and Prentiss gives Zoey a shocking message.

Jackie is ambushed by Antoinette. Coop's dream finally comes true.

Jackie detoxes at home - with help. Frank raises an objection about Grace.

Jackie learns about a DEA investigation at the hospital that will require her to take a urine test, so she plots to get around it. Meanwhile, Kevin and Mia plan their wedding; the homeless nun returns in worse shape than ever; and Coop and Carrie find a way to skirt their no sex in the hospital rule.

Jackie breaks up with Frank and tries to separate herself from the people closest to her so she can keep using drugs. Meanwhile, Carrie forgets Coop's 40th birthday; the DEA investigation intensifies; and Zoey decides to become a nurse practitioner.

Jackie reluctantly attends Kevin's wedding. Carrie makes demands on Coop.

Coop gets a surprise. Jackie hits the road. Season finale.