Jo and Blair have a hard time adjusting to college.

Ms Garret decides to re-open an abandoned department store and turn it into her own.

Blair is dying to join the sorority that's she pledging and she volunteers Mrs. Garrett to be the caterer for a rush party. However, when Mrs. Garrett begins making Mexican before consulting Blair, who wanted Chinese, Blair fires her without a second thought.

Jo's been dating, Bill, a plain guy who attends the same college as she does, but when she learns that he's a rich kid, Jo becomes resentful and angry that he didn't tell her the whole truth about himself.

Tootie's new boyfriend, Jeff, is the star football player on the football team at Eastland. However, she learns a startling secret that he's been keeping, he's illiterate. She now must decide whether or not to encourage his behavior of having other kids do his work for him.

A strange man tells the girls that years ago a murder occurred in the shop. Later, when the girls see Mrs. Garret with a knife they assume that she's possessed by the murderer's spirit and is out to get them.

Natalie is allowed to enroll in a college course at Langley College and she quickly gets an overblown ego which quickly threatens her friendships with Blair, Jo and Tootie. Things get even worse when she learns that if she can keep her grade point average up she will be allowed to graduate early and enroll at Langley in the fall.

For a birthday surprise, the girls take Mrs. Garrett to a club featuring male exotic dancers, but the one who's in for the real surprise is Blair.

Streetwise Kelly alleges that the vandalism of Edna's Edibles was the work of a local gang, but Jo decides to investigate.

Mrs. Garrett is slowly losing business to a competitor, Pete Dawson. However, Natalie, with the help of her computer, breaks into his computer and alters his recipes.

Jo begins seeing sparks between her divorced parents and immediately hopes they get back together. However, her hopes quickly become dashed when she learns that her father is planning to marry another woman.

The holidays bring joy to the girls when they all plan on going home for Christmas but when Jo's mother temporarily moves to Miami, Jo is stuck in Peekskill.

While Mrs. Garrett frets over an inspection by the Board of Health, the girls get involved with a chain letter and ignore their responsibilities.

A young boy enters Edna's Edibles and Tootie befriends him and learns that he lives next door. She also learns that his mother works all day and leaves him home alone and tells him never to leave their apartment and when a gas leak is detected on the block the young boy won't budge.

Natalie starts dating a black guy, and Tootie thinks that Natalie hates him because of his color.

Newly elected board member Jo tackles the regents of Langley when they vote to cut academic scholarships in favor of a scoreboard nobody wants.

The girls are shaken by the sudden death of Natalie's father and wonder how to ease her pain.

Blair is distraught when she discovers that Jo has taken her place in popularity on campus. This leads to an argument between the two that ends with Jo refusing Blair's help for planning a party.

Blair and her boyfriend, Cliff, are serious at least Cliff thinks so but Blair pushes him away. Meanwhile, a movie star, Heather Hunt, is visiting Peekskill and quickly Blair finds herself competing with her for Cliff's attentions.

A marriage proposal from Blair's boyfriend prompts her to begin dreaming about the future for herself and her friends.

Tootie's mother comes to Eastland for a visit, and the fact that Tootie doesn't communicate with her mother becomes apparent. Her mother quickly realizes there are many things she doesn't know about her daughter and wants to have an open relationship with Tootie but will Tootie allow that?

Geri is in charge of organizing a charity auction but makes her first mistake by making Blair her assistant. Blair quickly takes over and begins doing things without consulting Geri. Geri in turn fires her and makes her second mistake, not accepting any help from from anyone.

Mrs. Garrett's son, Raymond stops by Edna's Edibles for a visit and brings along his wife, Doris, whom he has been having marital problems with. This gets Mrs. Garrett and the girls worried about the future of the shop especially since Raymond and Doris have been talking about a divorce.

Another school year has come to an end and all the girls are preparing or their summer vacation. They each reminisce about the last six years they have spent together (via flashbacks). However, leaving one another on good terms is something that may not happen when an accident causes yet another rift between Jo and Blair.

Flashbacks and memories of the past continue as the girls finish getting ready for their summer vacations. However, saying goodbye to one another appears to be easy for all them especially since fights are brewing between Blair and Jo and Natalie and Tootie.