Kentucky Jones is a half-hour comedy/drama starring Dennis Weaver as Kenneth Yarborough "K.Y. or Kentucky" Jones, D.V.M., a recently widowed former horse trainer and active rancher, who becomes the guardian of Dwight Eisenhower "Ike" Wong, a 10-year-old Chinese orphan, played by Ricky Der. Harry Morgan, previously of the CBS sitcoms December Bride and Pete and Gladys, was featured in the series as Seldom Jackson, a former jockey who assists Dr. Jones. Cherylene Lee appears as Annie Ng, Ike's friend. Arthur Wong portrays Mr. Ng, Annie's father. Keye Luke stars as Mr. Wong, a friend of Dr. Jones. Nancy Rennick appears as Miss Throncroft, a social worker. Kentucky Jones, which ran on NBC from September 19, 1964, to September 11, 1965, was the first of Weaver's four series, the most successful having been McCloud, since he left the role of the marshal's helper Chester Goode on CBS's western classic Gunsmoke, starring James Arness.

Richard Bull, who later portrayed the henpecked storekeeper Nels Oleson on NBC's Little House on the Prairie, appeared twice on Kentucky Jones as Harold Erkel in episodes entitled "The Victim" and "The Return of Wong Lee".