We meet the Stratford sisters, Kat and Bianca, two very different people with very different views in life. They start at a new high school Padua High School with one thing in common, they both know strategy is the key. Kat wants to save the world and get out of high school as fast as she can, while Bianca wants to climb the ladder of high school popularity as fast as possible. Can each sister find happiness after getting off to a very rocky start?

Kat learns that first impressions aren't everything when she makes a shocking discovery about Patrick. Meanwhile, Bianca decides that it's time to rid herself of her squeaky clean persona. To do this, she starts a rumor about her recent conquests with an older guy. After hearing all of the rumors, Cameron's feelings are instantly hurt.

Kat stages a protest after Padua High enforces a new security policy and school uniforms, while Cameron has a hard time getting over Bianca who is sneaking around with newly single Joey.

In the mid-season premiere episode, Kat and Patrick are caught skipping school and both get suspended. How will Kat deal with a suspension after learning it might ruin her GPA, potentially destroying her dream to get into a prestigious college? Meanwhile, Bianca has her own problems after a secret make-out session with Joey is caught on video. Will Chastity watch the security tape before Bianca gets the chance to erase the evidence?