Blanche's daughter, Rebecca has some wonderful news. She's going to become a mother, through artificial insemination. However, Blanche is less then thrilled, she's totally against the entire thing.

Sophia's friend has come up with an idea that will change her life. She wants to commit suicide and she wants Sophia there to hold her hand. Meanwhile, Blanche, Rose and Dorothy become singing nursemaids to a sick baby that they are taking care of for the weekend.

Blanche tries to lure men by placing a fake ad in the paper trying to sell a Mercedes. Meanwhile, Rose has to deal with meeting Miles's daughter who makes it clear she wants their relationship to be no more and Dorothy discovers Sophia is hoarding Social Security money, thanks to a computer error.

An FBI agent investigates the girls' life's for a possible visit from President Bush. This leads the girls to reminisce about times they have spent together.

Blanche's daughter wants to give birth in a birthing center while Blanche is preoccupied by the possibility of Rebecca delivering in a local hospital. Blanche doesn't want to be embarrassed by the fact that her daughter was artificially inseminated.

Both Sophia and Rose take advice from Blanche that lands each of them in hot water. Due to a drought in St. Olaf, Rose swears to be celibate and Blanche advises her not to tell Miles the truth. While Sophia takes Blanche's tips to lure a man to bed but when she tells him she loves him, he doesn't respond with what she hoped.

Totally against Dorothy and Stan's impending nuptials, Sophia vows to not let the ceremony go off. Meanwhile, Blanche begins interviewing for a new roommate since Dorothy is planning to move out.

While babysitting for her granddaughter, a man mistakes Blanche as being the baby's mother and Blanche does nothing to set him straight. Meanwhile, Sophia gets ready for the Festival of the Dancing Virgins, a celebration of mothers and daughters but Dorothy wants no part of it.

After Miles gives Rose a friendship ring, Rose becomes convinced Charlie is trying to contact her from the grave with the message that he disproves of her relationship with Miles. Meanwhile, Blanche begins coaching her new baseball player boyfriend.

A man Blanche has no memory of returns from the Persian Gulf in hopes of fulfilling the promise she supposedly made to him before he left, that she will be his and only his. Meanwhile, Sophia has Rose help her write up her will.

Dorothy is contacted by a high school teacher she once had a crush on. They quickly begin seeing each other and Dorothy is convinced his feelings are genuine. Meanwhile, Rose puts together a talk show.

Rose is upset when she has missed her high school reunion due to being sick, so Blanche convinces her, Dorothy and Sophia to crash a reunion held in Miami, posing as absentees from that school. Dorothy goes as the lame prom queen Cindy Lou Peoples, Blanche is Susan, Rose is the Korean exchange student Kim FongToi and Sophia is Mrs. Gonzales. With that, the girls mingle with their "former" classmates, only to realize that their counterparts lives are as dull as theirs, however, when the girls are found out by the guests...Rose has a heart attack!