In the season six premiere TMS pays tribute to metal god and icon Ronnie James Dio; Geezer Butler and Vinny Appice from Black Sabbath and Heaven and Hell talk about the passing of Ronnie James Dio; Wendy Dio talks about how she met Ronnie James Dio and their marriage; Rob Halford and Tom Morello talk about the musical influences Ronnie James Dio have had on them; in the Throwdown the hosts, Halford and Morello debate which Ronnie James Dio band was the best: Rainbow or Black Sabbath; and Craig Goldy, former Dio guitarist, is featured as the guest guitarist.

Michael Anthony, former Van Halen bassist is interviewed and talks about if he knows why he isn't in Van Halen anymore, the differences between Eddie Van Halen and Joe Satriani; Kip Winger and Carrie Keagan are interviewed and talk about their new show Rock 'n' Roll Fantasy Camp; in the Throwdown the hosts and guests debate which Van Halen album was the best: 1984 or 5150; in the Top 5 the hosts put together their definitive list of live albums; and the guest guitarist features Tracii Guns.

Philip Anselmo, lead vocalist for Pantera is interviewed and talks about the anniversary of Cowboys from Hell, how the band got their first record deal; Bruce Kulick, former KISS guitarist is interviewed and talks about his new album BK3; in the Throwdown the guests and hosts debate which band would be considered in the Big 4, if it was expanded to the Big 5: Overkill, Exodus or Testament; in the Top 5 the hosts put together their definitive list of album covers; and the guest guitarist features George Lynch.

Phil Collen, lead guitarist from Def Leppard is interviewed; Frankie Banali, drummer for Quiet Riot is interviewed; in the Throwdown the guests and hosts debate which Def Leppard album was better: High 'n' Dry or Pyromania; in the Top 5 the hosts put together their definitive list of power ballads; and the guest guitarist features Richie Kotzen.

Bill Ward, drummer and a founding member of Black Sabbath is interviewed; Glenn Danzig is interviewed; in the Throwdown the guests and hosts debate which album is better: Ozzy Osbourne's Blizzard of Ozz or Black Sabbath's Heaven and Hell; in the Top 5 the hosts put together their definitive list of debut albums; and the guest guitarist features Richie Kotzen.

Jason Bonham, son of Led Zeppelin drummer John Bonham and drummer for Black Country Communion is interviewed; Rikki Rockett, drummer for Poison is interviewed; in the Throwdown the guests and hosts debate which Led Zeppelin album was the best: Led Zeppelin II or Led Zeppelin IV; in the Top 5 the hosts put together their definitive list of metal guitarists; and the guest guitarist features Craig Goldy.

Slash is interviewed and talks about his new album Slash, working with different singers on the album, if he would rather work with Axl Rose or Scott Weiland again; Myles Kennedy from Alter Bridge is interviewed; in the the Throwdown the guests and hosts debate which Slash Band was better: Slash's Snakepit or Velvet Revolver; in the Top 5 the hosts put together their definitive list of thrash albums; and the guest guitarist features George Lynch.

The hosts look back at show outtakes and backstage footage from the sixth season of TMS.