Owen Wilson hosts Saturday Night Live on October 2, 2021, with musical guest Kacey Musgraves.

Kim Kardashian West hosts Saturday Night Live on October 9, 2021 with musical guest Halsey.

Rami Malek hosts Saturday Night Live on October 16, 2021 with musical guest Young Thug.

Jason Sudeikis hosts Saturday Night Live on October 23, 2021 with musical guest Brandi Carlile.

Kieran Culkin hosts Saturday Night Live on November 6, 2021 with musical guest Ed Sheeran.

Simu Liu hosts Saturday Night Live on November 20, 2021 with musical guest Saweetie.

Billie Eilish hosts and performs as the musical artist. Kate McKinnon returns presenting the CDC Players.

Actor and People's sexiest man of 2021 hosts.

Ariana DeBose hosts Saturday Night Live on January 15, 2022 with musical guest Bleachers.

Will Forte hosts Saturday Night Live on January 22, 2022 with musical guest Måneskin.

Willem Dafoe hosts Saturday Night Live on January 29, 2022 with musical guest Katy Perry.

John Mulaney hosts Saturday Night Live on February 26, 2022 with musical guest LCD Soundsystem.

Oscar Isaac hosts Saturday Night Live on March 5, 2022 with musical guest Charli XCX.

Zoë Kravitz hosts Saturday Night Live on March 12, 2022 with musical guest Rosalía.

Jerrod Carmichael hosts Saturday Night Live on April 2, 2022 with musical guest Gunna.

Jake Gyllenhaal hosts Saturday Night Live on April 9, 2022 with musical guest Camila Cabello.

Lizzo hosts and performs as musical guest on Saturday Night Live on April 16, 2022.

Benedict Cumberbatch hosts Saturday Night Live on May 7, 2022 with musical guest Arcade Fire.

Selena Gomez hosts Saturday Night Live on May 14, 2022 with musical guest Post Malone.

Natasha Lyonne hosts Saturday Night Live on May 21, 2022 with musical guest Japanese Breakfast.