Peter Parker's nerdy high-school friend, Max, is hazed in a deadly fraternity prank that turns him into Electro, a high-voltage villain that threatens the campus. Only Spider-Man can stop him from exacting his revenge on the students.

The master martial artist and swordswoman, Shikata, is sent to capture Spider-Man for a wealthy man's collection of rare animals; and Shikata determines that Spider-Man is too noble a foe to simply capture, so they must fight to the death.

Peter's professor, Doc Connors, injects himself with reptilian DNA, which slowly changes him into the angry, vengeful Lizard; and since the serum affects Doc Connors' brain, Spider-Man must stop his beloved professor as he begins seeking revenge on those who have harmed him, including Harry.

Spider-Man is out to catch Talon, a female thief who is responsible for high-risk robberies in the city. Things get complicated when Spidey finds out that Talon is his best friend Harry's new girlfriend.

A team of three ex-KGB agents called Pterodax take people hostage, including Peter and Indy, his new crush. They want Spider-Man, so Peter must figure out a way to appease Pterodax without revealing his alter ego.

Electro returns from his seeming death and tries to make Sally, a girl he has a crush on, become an electrical being just like him.

Peter covers a press conference and inadvertently videotapes incriminating evidence against Silver Sable, an Eastern European assassin for hire. Now she will stop at nothing — including killing Mary Jane, Harry, and Indy — to get the tape back.

Spider-Man is duped by the infamous Kingpin into stealing the TX-1 super-chip, designed to decrypt the confidential satellite transmissions that drive the world's financial markets. Now he must find a way to get it back.

Spider-Man battles Turbo Jet, a modern-day Robin Hood armed with a homemade propulsion system, who steals from the wealthy and gives to the poor. Spidey's life gets even harder as the public rallies around Turbo Jet – and against Spider-Man.

Dr. Zellner tests his "smart drug" on Peter Parker foe Flash Thompson, and Flash immediately displays dramatic spikes in intellect. However, along with the IQ boost comes a potentially fatal side effect. With only minutes to find an antidote, Zellner takes Flash's suggestion that he experiment on an already intelligent candidate: Peter Parker.

The Gaines Twins, a brother and sister with uncanny telepathy, escape from an armored transport convoy, but Spider-Man apprehends them by overcoming their brain blasts with his own superhuman will power. Later, just as Spider-Man reveals to MJ that he's really Peter Parker, Kraven the Hunter confronts Spider-Man. As payback for the years he spent in jail, Kraven attacks MJ with one of his poison darts. Spider-Man rushes to her side too late, as her life slowly slips away. Now, Peter is out for revenge.

Spider-Man realizes that the diabolical Gaines Twins have brain-blasted him into believing that MJ has died at the hands of Kraven the Hunter. He corners the Twins, but things take a turn for the worse when they once again use their telepathy to trick him.