Peter Parker's nerdy high-school friend, Max, is hazed in a deadly fraternity prank that turns him into Electro, a high-voltage villain that threatens the campus. Only Spider-Man can stop him from exacting his revenge on the students.

The master martial artist and swordswoman, Shikata, is sent to capture Spider-Man for a wealthy man's collection of rare animals; and Shikata determines that Spider-Man is too noble a foe to simply capture, so they must fight to the death.

Peter's professor, Doc Connors, injects himself with reptilian DNA, which slowly changes him into the angry, vengeful Lizard; and since the serum affects Doc Connors' brain, Spider-Man must stop his beloved professor as he begins seeking revenge on those who have harmed him, including Harry.

Spider-Man is out to catch Talon, a female thief who is responsible for high-risk robberies in the city. Things get complicated when Spidey finds out that Talon is his best friend Harry's new girlfriend.

A team of three ex-KGB agents called Pterodax take people hostage, including Peter and Indy, his new crush. They want Spider-Man, so Peter must figure out a way to appease Pterodax without revealing his alter ego.

Peter Parker's lab partner Christina reads his mind with her new invention: an ESP crown. The crown malfunctions, jolting her own brain with electricity and altering her reality. No longer able to distinguish fantasy from reality, Christina attempts to kill M.J. in order to limit the competition for Spider-Man's eternal affection.

Electro returns from his seeming death and tries to make Sally, a girl he has a crush on, become an electrical being just like him.

Peter covers a press conference and inadvertently videotapes incriminating evidence against Silver Sable, an Eastern European assassin for hire. Now she will stop at nothing — including killing Mary Jane, Harry, and Indy — to get the tape back.

Spider-Man is duped by the infamous Kingpin into stealing the TX-1 super-chip, designed to decrypt the confidential satellite transmissions that drive the world's financial markets. Now he must find a way to get it back.

Dr. Zellner tests his "smart drug" on Peter Parker foe Flash Thompson, and Flash immediately displays dramatic spikes in intellect. However, along with the IQ boost comes a potentially fatal side effect. With only minutes to find an antidote, Zellner takes Flash's suggestion that he experiment on an already intelligent candidate: Peter Parker.

The Gaines Twins, a brother and sister with uncanny telepathy, escape from an armored transport convoy, but Spider-Man apprehends them by overcoming their brain blasts with his own superhuman will power. Later, just as Spider-Man reveals to MJ that he's really Peter Parker, Kraven the Hunter confronts Spider-Man. As payback for the years he spent in jail, Kraven attacks MJ with one of his poison darts. Spider-Man rushes to her side too late, as her life slowly slips away. Now, Peter is out for revenge.

Spider-Man realizes that the diabolical Gaines Twins have brain-blasted him into believing that MJ has died at the hands of Kraven the Hunter. He corners the Twins, but things take a turn for the worse when they once again use their telepathy to trick him.